Infectious complications with the use of cyclosporine versus azathioprine after cadaveric kidney transplantation |
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| Authors: | D Shaffer S M Hammer A P Monaco |
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| Affiliation: | 1. Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Unit of Infectious Disease, Microbiology and Preventive Medicine, Spain;2. Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III, Madrid, Spain;3. Unit of Nephrology and Urology, Spain;4. Service of Clinical Pharmacology, Spain;5. Hepatobiliary and Pancreatic Surgery and Hepatic Transplant Unit, Spain;6. Service of Cardiology, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain;1. Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering and Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China;2. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan;1. GSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy;2. GSK, Siena, Italy |
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| Abstract: | Infectious complications within 1 year of cadaveric kidney transplantation were compared in 45 patients treated with azathioprine, prednisone, and antilymphocyte globulin and 38 patients treated with cyclosporine and prednisone. Although there was no difference in the 1 year patient or graft survival rate, cyclosporine-treated patients had significantly fewer wound infections, infection-related transplant nephrectomies, and infection-related graft failures than azathioprine-treated patients. The cyclosporine-treated diabetic recipients had more nonviral pneumonias and opportunistic infections but fewer cases of infection-related transplant nephrectomy than did the azathioprine-treated diabetic patients. Our data suggest cyclosporine is associated with reduced infectious morbidity after cadaveric kidney transplantation in nondiabetic patients. |
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