抗人球蛋白试验阳性与恶性血液病的关联性及输血治疗的探讨

目的：恶性血液病常合并自身免疫性溶血性贫血，对血液科抗人球蛋白试验阳性患者进行统计分析，探讨疾病的关联性和输血治疗的方向。方法：采用微柱凝集法对患者血样做抗人球蛋白试验，包括直接抗人球蛋白试验（DAT）和间接抗人球蛋白试验（IAT）。结果：263例抗人球蛋白试验中阳性为69例，直抗（DAT）和间抗（IAT）均阳性有4例，单纯DAT阳性65例。其中原发性阳性率占7．2％，继发性占17．5％。结论：恶性血液病会继发自身免疫性溶血，并且对溶血性贫血的患者先申请做直接和间接抗人球蛋白试验，清楚发生溶血的原因后再申请用何种成分红细胞输血治疗，以达到理想的输血效果。

The discussion of relevance and transfusion treatment between coombs test positive and malignant hematologic disease

Objective ： hematologic malignancy often merge into autoimmune hemolytic anemia. Statistical analysis coombs＇ test positive patients to discuss the relevance of disease and the direction of blood transfusion treatment. Methods ： Using rnicrocolumn agglutination to do coombs＇ test on the patients＇ blood samples, including DAT and IAT.Results ： 69 out of 263 cases were positive, which DAT and IAT each has 4 cases, and pure DAT has 65 cases. Primary positive accounts for 7.2%,secondary positive accounts for 17.5%. Conclusions ： hematologic malignancy will secondary autoimmune hemolytic, therefore hemolytic anemia patients first apply for DAT and IAT to help finding out the reasons of hemolysis, then use the fight red blood cell transfusion treatment in order to achieve the ideal effect of blood transfusion.