| 内标法测定奥扎格雷钠颗粒的含量 |
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| 引用本文： | 张勇,陈玉威,高桂花. 内标法测定奥扎格雷钠颗粒的含量[J]. 实用药物与临床, 2013, 16(6): 517-519 |
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| 作者姓名： | 张勇 陈玉威 高桂花 |
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| 作者单位： | 1. 辽宁省药物研究院,沈阳,110015
2. 济宁医学院药学院,山东日照,276826 |
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| 摘 要： | 目的建立内标法测定奥扎格雷钠颗粒含量。方法采用C18柱,以0.02 mol/L乙酸铵溶液-甲醇(75∶25)为流动相,流速:1.0 mL/min,柱温:25℃,检测波长:276 nm。结果浓度在0.028～0.066 mg/mL范围内具有良好的线性关系(r=0.999 9),平均回收率为99.37%,RSD为0.92%(n=9),精密度RSD为1.07%(n=6)。结论该方法简便、快速、专属性强,能满足制剂质量标准的要求。
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| 关 键 词： | 奥扎格雷钠 内标法 高效液相色谱法 |
Determination of ozagrel sodium granules by internal standard method |
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| ZHANG Yong , CHEN Yu-wei , GAO Gui-hua. Determination of ozagrel sodium granules by internal standard method[J]. Practical Pharmacy and Clinical Remedies, 2013, 16(6): 517-519 |
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| Authors: | ZHANG Yong CHEN Yu-wei GAO Gui-hua |
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| Affiliation: | 1.Liaoning Institute of Pharmaceutical,Shenyang 110015,China;2.School of Pharmacy,Jining M edical University,Rizhao 276826,China) |
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| Abstract: | Objective To establish a method to determine ozagrel sodium granules by internal standard method.Methods The analysis w as conducted w ith C18 column,and the column temperature w as 25 ℃,the mobile phase consisted of 0.02 mol / L ammonium acetate solution-methanol(75∶ 25) w ith the flow rate of 1.0 mL / min,the detection w avelength w as at 276 nm.Results A good linear relationship existed in 0.028 ～ 0.066 mg / mL(r = 0.999 9),the average recovery rate w as 99.73%,RSD = 0.92%(n = 9),the RSD of precision w as 1.07%(n = 6).Conclusion The method is simple,rapid,highly specific and can meet the requirements of the standard of quality of the preparations. |
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| Keywords: | Ozagrel sodium Internal standard method HPLC |
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