万古霉素血清药物浓度监测及临床应用分析

目的分析万古霉素血清药物浓度监测及临床应用的合理性,为提高万古霉素应用的合理性提供参考。方法回顾性分析2010年9月至2012年11月在我院住院期间进行万古霉素血清药物浓度监测的病例,统计分析后得到万古霉素应用存在的问题。结果共入选病例78例,发现临床中万古霉素血清药物浓度监测及临床应用存在诸多问题,主要表现为无指证用药、给药速度不标明或标注不准确、应用剂量偏低、对特殊情况下的剂量调整方法不当以及靶谷浓度的选择不当、监测时机不当等。结论针对临床中实际存在的应用问题,通过建立万古霉素应用标准及鼓励临床药师参与万古霉素药物治疗等一系列措施,提高万古霉素应用的合理性。

Analysis of drug concentration monitoring on serum and clinical rational use of vancomycin

Objective To analyse the rationality of drug concentration monitoring on serum and clinical rational use of vancomycin and to provide a reference for clinical rational use of vancomycin.Methods Analysis w as retrospectively carried out in the inpatients admitted w ho w ere prescribed vancomycin and drug concentration monitoring in serum to find out application problems of vancomycin by the statistical analysis from September 2010 to November 2012.Results Many problems w ere found out in the respects of drug concentration monitoring in serum and clinical rational use of vancomycin in a total of 78 cases w hich w ere displayed by no drug indication,improper injection speed,inadequate drug dosage,improper dose adjustment,the improper selection of trough concentration and monitoring opportunity.Conclusion According to the common and practical problems in application of vancomycin,a series of measures can effectively improve the rational application of vancomycin through the establishment of vancomycin standards and encouraging clinical pharmacists to participate in drug treatment of vancomycin.