| 胰岛素受体底物-2基因1057G/D多态性与妊娠期糖尿病的相关性 |
| |
| 引用本文： | 曾 玉,黄培林,顾平清.胰岛素受体底物-2基因1057G/D多态性与妊娠期糖尿病的相关性[J].临床检验杂志,2010,28(1):50-52. |
| |
| 作者姓名： | 曾 玉 黄培林 顾平清 |
| |
| 作者单位： | 东南大学临床医学院;南京市妇幼保健院检验科;东南大学基础医学院; |
| |
| 摘 要： | 目的研究胰岛素受体底物-2(IRS-2)基因1057G/D多态性在南京地区汉族孕妇中的频率分布及其与妊娠期糖尿病(GDM)患者胰岛素抵抗的相关性。方法采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)检测110例GDM孕妇(GDM组)及100例正常孕妇(NGT组)IRS-2基因1057G/D等位基因分布及基因频率,同时测定所有研究对象的空腹血糖(FPG)、空腹胰岛素(FIns),并计算胰岛素抵抗指数(HOMA-IR)以评价胰岛素抵抗状态。结果①IRS-2基因1057 D等位基因频率在GDM和NGT组中分别为25.91%和31.50%,差异无显著意义(P>0.05);②与NGT组相比,GDM组的FPG、FIns和HOMA-IR明显升高,差异有显著意义(P<0.05)。③GDM组和NGT组中不同基因型孕妇FPG、FIns和HOMA-IR等差异均无显著性(P>0.05)。结论南京地区汉族孕妇中IRS-2基因1057G/D多态性可能与妊娠期糖尿病的发生和胰岛素抵抗状态无关。上述结果尚待进一步通过联合检测和扩大样本量来确认。
|
| 关 键 词： | 妊娠期糖尿病 胰岛素受体底物-2 单核苷酸多态性 |
| 收稿时间： | 2009/3/19 0:00:00 |
| 修稿时间： | 2009/9/14 0:00:00 |
Association of insulin receptor substrate-2 gene 1057G/D polymorphism with gestational diabetes mellitus |
| |
| ZENG Yu,HUANG Peilin and GU Pingqing.Association of insulin receptor substrate-2 gene 1057G/D polymorphism with gestational diabetes mellitus[J].Chinese Journal of Clinical Laboratory Science,2010,28(1):50-52. |
| |
| Authors: | ZENG Yu HUANG Peilin and GU Pingqing |
| |
| Institution: | 1.School of Medicine/a>;Southeast University/a>;Nanjing 210009/a>;2.Department of Clinical Laboratory/a>;Nanjing Obstetric and Gynecology Hospital/a>;Nanjing 210004/a>;3.School of Basic Medical Science/a>;China |
| |
| Abstract: | Objective To investigate the frequency of insulin receptor substrate-2(IRS-2) gene 1057G/D polymorphism in pregnant women of Chinese Han population in Nanjing and its effects on insulin resistance in women with gestational diabetes mellitus(GDM).Methods The genotypes of IRS-2 1057G/D polymorphism were determined in 110 GDM patients and 100 healthy pregnant women by PCR-restriction fragment length polymorphism(RFLP).Serum levels of glucose and insulin were estimated by biochemical methods.Homeostasis model a... |
| |
| Keywords: | gestational diabetes mellitus insulin receptor substrate-2 single nucleotide polymorphism |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《临床检验杂志》浏览原始摘要信息 |
| 点击此处可从《临床检验杂志》下载免费的PDF全文 |
