Protective effect of Shemamruthaa on lipids anomalies in 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma-bearing rats

The objective of this work was to evaluate the beneficial effect Shemamruthaa (a siddha formulation which constitutes Hibiscus rosa sinensis, Emblica officinalis, and Honey in define ratio) on lipid metabolism in 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma-bearing rats. Lipid profile and lipid-metabolizing enzyme were investigated in serum, liver, and kidney of DMBA-induced mammary carcinoma-bearing SD rats. The levels of total cholesterol, free cholesterol, phospholipids, triglycerides, and free fatty acids were significantly increased, whereas, the levels of ester cholesterol were significantly decreased in plasma, liver and kidney of cancer-bearing animals, and those levels were restored to near normal levels upon treatment with SM. Moreover, the activities of total lipase, cholesterol ester synthase, and cholesterol ester hydrolase were found to be increased, and lipoprotein lipase and lecithin cholesterol acyl transferase were decreased in cancer-bearing animals. In addition, the levels of very low-density lipoprotein and low-density lipoprotein were increased, and the level of high-density lipoprotein was decreased. These alterations were recouped back upon treatment with SM when compared to cancer animals. The result indicated that Shemamruthaa administration plays a beneficial role in regulating lipid profile and lipid-metabolizing enzymes in cancer-suffering animals.