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A systematic study on the chemical stability of the novel indoloquinone antitumour agent EO9 |
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| Authors: | J D de Vries J Winkelhorst W J M Underberg R E C Henrar and J H Beijnen |
| Institution: | a Department of Pharmacy, Slotervaart Hospital/Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands b Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands c EORTC-NDDO, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands |
| Abstract: | The chemical stability of the new anticancer drug EO9 in aqueous solution has been investigated utilizing a stability-indicating reversed-phase high-performance liquid Chromatographie assay with ultraviolet detection and ultraviolet spectrophotornetry. The degradation kinetics of EO9 have been studied as a function of pH, buffer composition, ionic strength and temperature. A pH-rate profile, using rate constants extrapolated to zero buffer concentration, was constructed demonstrating that EO9 is most stable in the pH region 8–9. The degradation mechanism of EO9 in aqueous solution is discussed. |
| Keywords: | EO9 Chemical stability Degradation kinetics |
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