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Pregnancy-associated plasma protein A in non-cardiac conditions |
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| Authors: | Iversen Kasper Karmark Teisner Ane Sogaard Teisner Borge Kliem Anette Bay Morten Kirk Vibeke Nielsen Henrik Boesgaard Soren Grande Peer Clemmensen Peter |
| Affiliation: | aThe Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark bCopenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark cThe London Bridge Fertility, Gynaecology and Genetics Centre, London, UK dDepartment of Immunology and Microbiology, University of Southern Denmark, Odense, Denmark |
| Abstract: | ObjectivePAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.Design and methodsPAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.ResultsPAPP-A was detectable (≥ 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1–6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p = 0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.ConclusionPAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease. |
| Keywords: | Pregnancy-associated plasma protein A Specificity Coronary artery disease Non-cardiac conditions |
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