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Effects of whole blood interfacial interactions on potassium ion transport through poly(2-hydroxyethylmethacrylate) membranes |
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| Authors: | G. S. Margules J. A. Kane A. R. Livingston D. C. MacGregor |
| Affiliation: | (1) Cordis Research Corporation, PO Box 025700, ATC-2M, 33102 Miami, FL, USA;(2) Department of Biomedical Engineering, University of Miami, 33124 Coral Gables, FL, USA;(3) Department of Surgery, University of Toronto, M5G 1L5 Toronto, Ontario, Canada |
| Abstract: | Transport chamber experiments were conducted to elucidate the role of surface-oriented blood cell/serum protein interactions in modulating the potassium ion (K+) transport properties of poly (2-hydroxyethylmethacrylate) (pHEMA) membranes. The effects were achieved by carefully exposing one side of pHEMA membranes to freshly drawn whole blood for a period of 10 min. A simple steady-state diffusion model is presented and verified for both the control and experimental membranes. The results indicate that the presence of blood components rapidly decreases the rate of K+ transport to a new steady-state value which is described by a surface area multiplication factor of γT≃0.60. This observation is useful in the design of medical devices for biomedical electroanalysis and haemodialysis, where ion transport is the main function. This transport chamber approach is flexible and useful in measuring the effects of various microenvironmental manipulations to simulate variousin vivo conditions. |
| Keywords: | Blood cell interactions Diffusion Ion transport Poly (2-hydroxyethyl-methacrylate) |
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