无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效

目的：探讨无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床效果。方法将我院2010～2013年112例慢性阻塞性肺疾病合并呼吸衰竭患者随机分为对照组和实验组，每组各56例，其中对照组采用常规治疗，而实验组采用无创正压通气治疗。比较两组患者的住院时间、插管率、病死率以及治疗前后血气分析的指标（氧分压、二氧化碳分压、pH）。结果对照组住院时间、插管率和病死率均明显高于实验组，差异有统计学意义（P＜0.05）。两组患者在治疗前氧分压、二氧化碳分压、pH间比较差异无统计学意义（P＞0.05），但治疗后对照组氧分压低于实验组，二氧化碳分压高于实验组，差异有统计学意义（P＜0.05）。对照组中插管率为15.00%，而实验组插管率为3.57%，差异有统计学意义（P＜0.05）。结论无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭效果较好，改善预后，降低并发症发生率，值得临床推广。

Effect of noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure

Objective To explore the effect of noninvasive positive pressure ventilation on chronic obstructive pulmonary disease complicated with respiratory failure. Methods A total of ll2 chronic obstructive pulmonary disease patients with complication of respiratory failure admitted from 2010 to 2013 were selected, and randomly divided into control group and experimental group by half in which the control group using conventional treatment, while the experimental group using noninvasive positive pressure ventilation treatment. Then comparing hospitalization, intubation rate, mortality and indicators of blood gas analysis before and after treatment （for example partial pressure of oxygen, carbon dioxide partial pressure, pH）. Results Hospitalization, intubation and mortality rates were compared between two groups, the indicators for control group were significantly higher than the experimental group, the difference was statistically significant （P 〈 0.05）. Partial pressure of oxygen, partial pressure of carbon dioxide and pH were compared between two groups, the difference was without statistically significant （P〈0.05） before treatment, but the partial pressure of oxygen in the control group was lower than the experimental group after treatment, however the carbon dioxide partial pressure in the control group was higher than the experimental group after treatment, the difference was statistically significant （P 〈 0.05）.Intubation in the control group was 15.00%, while the experimental group was 3.57% intubation, the difference was statistically significant （P 〈 0.05）. Conclusion Noninvasive positive pressure ventilation is invasive, safe and effect on COPD complicated with respiratory failure. It deserves extensive clinical application.