韶关市腹泻患儿肠道腺病毒感染的分子流行病学调查

目的：对韶关市腹泻患儿肠道腺病毒感染进行分子流行病学调查分析。方法选取2010年1月～2013年12月韶关市腹泻患儿250例作为研究对象，收集其腹泻粪便并展开腺病毒检测。结果本次研究结果共检测出12例肠道腺病毒感染患儿，阳性率为4.80%（12/250）。12例肠道腺病毒（EAdV）感染患儿中，属于肠道腺病毒41型的9例，占3.60%（9/250）。属于肠道腺病毒40型的3例，占1.20%（3/250）。腺病毒感染主要集中在2岁以下的婴幼儿儿童，且发病率与性别、居住地、季节等因素之间无明显的联系，差异不显著（P＞0.05）。患儿主要表现出发热、腹泻以及呕吐的症状。结论肠道腺病毒感染是引起患儿腹泻的重要原因之一，主要以肠道腺病毒41型为主。加强对婴幼儿的监测，一旦发现感染，及时予以针对性的治疗，对改善患儿病情、促进预后具有十分重要的意义。

Molecular epidemiology survey of enteric adenovirus infection in children with diarrhea in Shaoguan

Objective To investigate and analyze the molecular epidemiology of enteric adenovirus infection in the children with diarrhea in Shaoguan. Methods 250 children with diarrhea in Shaoguan from January 2010 to December 2013 were selected as the study subjects and their diarrhea feces were collected to receive adenovirus detection. Results Twelve children with enteric adenovirus infection were detected, with a positive rate of 4.80%（12/250）. Of the 12 children with enteric adenovirus infection（EAdV）, 9 children had type 41 enteric adenovirus infection, accounting for 3.60%（9/250）. Three children had type 40 enteric adenovirus infection, accounting for 1.20%（3/250）. Enteric adenovirus infection mainly concentrated in the infants and young children under the age of 2 years, and its attack rate was not obviously related to the sex, residence, season and other factors, with no significant differences（P〉0.05）. The children mainly displayed fever, diarrhea and vomiting symptoms. Conclusion Enteric adenovirus infection is an important cause of diarrhea in children and is mainly caused by type 41 enteric adenovirus. Enhancing monitoring of infants and young children and offering timely and specific treatment once infection occurs are of important significance to improving the children＇s state of illness and promoting prognosis.