The effect of apomorphine on regional cerebral blood flow in schizophrenia |
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| Authors: | D G Daniel K F Berman D R Weinberger |
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| Institution: | Clinical Brain Disorders Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032. |
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| Abstract: | A double-blind, placebo-controlled crossover study of the effects of apomorphine on regional cerebral blood flow (rCBF) during a prefrontal cortex activation task was undertaken to explore the role of dopamine on cortical function. The subjects were eight drug-free, chronically psychotic patients; six patients had schizophrenia. In each, apomorphine increased the relative prefrontal flow. The results suggest that enhanced prefrontal dopamine activity may reverse deficits in prefrontal cortex metabolism in schizophrenia. |
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