| HJ-1型一氧化氮治疗仪在救治兔海水淹溺肺水肿中的研究 |
| |
| 引用本文： | 樊燕蓉,董文度,何京津,杜立,徐根兴,刘新卷,裴云,傅更峰,马国华. HJ-1型一氧化氮治疗仪在救治兔海水淹溺肺水肿中的研究[J]. 生物医学工程学杂志, 2002, 19(3): 526-528 |
| |
| 作者姓名： | 樊燕蓉 董文度 何京津 杜立 徐根兴 刘新卷 裴云 傅更峰 马国华 |
| |
| 作者单位： | 1. 第二军医大学,南京军医学院分子医学研究所,南京,210099
2. 北京分析仪器厂军事代表室,北京,100095 |
| |
| 摘 要： | 采用合作研制的HJ－1型一氧化氮高频喷射通气治疗仪用于兔海水淹溺肺水肿的救治，复制兔海水淹溺肺水肿模型，将兔随机分为3组：海水淹溺肺水肿对照组、4药组（海水淹溺肺水肿动物用4种药物和高频喷射通气治疗仪救治），NO组（在4药组基础上再用HJ－1型一氧化氮高频喷射通气治疗仪救治），用血气分析仪测定Pao2,Sao2,pH值，发现NO组血氧分压和血氧饱和度比对照组显著提高，动物的存活时间大大延长，并阻止了海水淹溺肺水肿向海水型呼吸窘迫综合征的转归，提示该仪器用于救治肺水肿类疾病安全有效。
|
| 关 键 词： | HJ－1型一氧化氮治疗仪 海水淹溺 一氧化氮 高频喷射通气 肺水肿 |
The Effect of HJ-1 NO-HFJV Respirator on Treating Pulmonary Edema Caused by Seawater Drowning |
| |
| Fan Yanrong Dong Wendu He Jingjin Du Li Xu Genxing Liu Xinjuan Pei Yun Fu Gengfeng Ma Guohua. The Effect of HJ-1 NO-HFJV Respirator on Treating Pulmonary Edema Caused by Seawater Drowning[J]. Journal of biomedical engineering, 2002, 19(3): 526-528 |
| |
| Authors: | Fan Yanrong Dong Wendu He Jingjin Du Li Xu Genxing Liu Xinjuan Pei Yun Fu Gengfeng Ma Guohua |
| |
| Affiliation: | Institute of Molecular Medicine, Nanjing Military Medical College, Nanjing 210099. |
| |
| Abstract: | The study was to observe the therapeutic effect of HJ-1 NO-HFJV respirator on treating pulmonary edema caused by seawater drowning. Seawater was infused into the rabbit's lung to establish the animal model of pulmonary edema casued by seawater drowning(PE-SWD). Then the animals were divided into three groups: simple PE-SWD model as control group, treat group(animal model treated with HFJV respirator and four medicines) and HFJV respiratior plus NO group. Pa O 2, Sa O 2 and pH were measured by the blood-gas analyzer. The survival time and seawater drowing-respiratiory distress syndrom(SW-RDS) were observed. The results showed that Pa O 2?Sa O 2 in NO group were remarkably higher than that of PE-SWD control group, and the survival time was longer than that of medicine treated group and the incidence of SW-RDS decreased to zero. We assume that HJ-1 NO-HFJV respirator is efficient on treating pulmonary edema. |
| |
| Keywords: | Nitric oxide(NO) High frequency jet ventilation(HFJV) Pulmonary edema |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
