心室复极化时程与自主神经系统关系的研究

目前，随着心血管疾病日益增多，国外有少量研究者开始分析心室极化时程变异（Ｒｅｐｏｌａｒｉｚｔｉｏｎ ｄｕｒａｔｉｏｎ ｖａｒｉａｂｉｌｉｔｙ，ＲＤＶ）某些心脏疾病会在心室复极化时程上会有所表现。我们用乌拉坦麻醉大白鼠，研究用阿托品阻断迷走神经前后，ＲＤＶ的变化规律。通过正常人体位变化来改变人体自主神经系统的平衡状态，以研究心室复极化时程与自主神经系统的关系，发现大白鼠的ＨＲＶ和ＲＤＶ的谱分析的峰值

A Study of the Relation Between Ventricular Repolarization Duration and Autonomic Nervous System

Cardiovascular disease is a growing problem recently. There has been a few attention in the study of ventricular repolarization duration variability. RDV is associated with some cardiac diseases. We studied vagal blockade effects on RDV in urethane-anesthetized rats. To study the relation between ventricular repolarization duration and autonomic nervous system in subjects, we changed the balance of autonomic nervous system by body posture. The HRV and RDV spectral analysis showed that HF peak was modulated by the frequency of controlled respiration. We also found a significant decrease in HFnu and increase in LF/HF in HRV and RDV during vagal blockade. There is a significant increase of LF/HF of subjects in HRV and RDV from supine to tilt, which is consistent with the state of autonomic nervous system. The result of our study is that the ventricular repolarization duration is dependent on the autonomic nervous system. The RDV analysis will be more helpful in the clinic. This approach will provide a more useful noninvasive evaluation of cardiac disease and function.