| 雷公藤预处理后异体移植神经的形态学研究 |
| |
| 引用本文： | 陈路,夏先学,蒋华.雷公藤预处理后异体移植神经的形态学研究[J].现代预防医学,2011,38(3):535-537,546. |
| |
| 作者姓名： | 陈路 夏先学 蒋华 |
| |
| 作者单位： | 1. 川北医学院附属医院,南允,637000
2. 成都市第二人民医院 |
| |
| 摘 要： | 目的]研究大鼠异体坐骨神经段经雷公藤多甙(雷公藤提取物)预处理后异体移植的形态学变化。方法]设实验组A组:异体坐骨神经段经雷公藤预处理后异体移植,B组:新鲜异体神经移植,术后口服雷公藤多甙5mg/(kg.d)5周,C组:自体右侧坐骨神经原位移植,D组:将供体直接移植于坐骨神经缺损模型。术后分时间段对移植神经片段进行形态学研究。结果]术后2周,A、B组移植神经段早期急性排斥反应稍重于C组,但小于D组;至8周时A、B组移植段的炎性细胞浸润程度明显减轻,与C组相似,而D组炎性细胞浸润明显;术后14周时A、B、C3组移植神经段外膜构成完整,束膜、内膜厚度,分布及范围无明显差异,再生大量神经纤维,髓鞘完整,排列规则,再生有髓神经神经纤维的面积,总数和髓鞘厚度差异无统计学意义(P﹥0.05),而D组基本未见神经纤维再生。结论]异体神经段经雷公藤多甙预处理后可降低免疫排斥反应,促进周围神经再生。
|
| 关 键 词： | 雷公藤 预处理 周围神经 异体移植 形态学 |
MORPHOLOGICAL STUDY OF DONOR NERVE PRETREATED BY TRIPTERYGIUM GLYCOSIDE AFTER ALLOGRAFT |
| |
| CHEN Lu,XIA Xian-xue,JIANG Hua.MORPHOLOGICAL STUDY OF DONOR NERVE PRETREATED BY TRIPTERYGIUM GLYCOSIDE AFTER ALLOGRAFT[J].Modern Preventive Medicine,2011,38(3):535-537,546. |
| |
| Authors: | CHEN Lu XIA Xian-xue JIANG Hua |
| |
| Institution: | CHEN Lu,XIA Xian-xue,JIANG Hua. (The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China) |
| |
| Abstract: | Objective] To study the morphological changes of Tripterygium Glycoside ( TG) after transplantation. Methods] 40 male SD rats were divided randomly into 4 groups: Group A: With TG pretreatment before transplantation. Group B: The fresh variant sciatic nerves were used for transplantion and TG 5mg/(Kg*d) were taken by mouth after transplantation for five weeks. Group C: The fresh sciatic nerves for transplantation were of their own. Group D: The fresh variant sciatic nerves were transplanted without any ot... |
| |
| Keywords: | Tripterygium Glycoside (TG) Pretreatment Peripheral nerve Allograft Morphology |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
