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Flagellate Dermatitis in a Child Most Likely Secondary to Doxorubicin
Authors:Darosa Lim M.D.  Marine Aussedat D.Pharm.  Nicole Maillet‐Lebel M.D.  Danielle Marcoux M.D.
Affiliation:1. Division of Dermatology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte‐Justine, Montreal, Quebec, Canada;2. Faculty of Medicine, Montreal University, Montreal, Quebec, Canada;3. Pharmacy Department, Research Unit in Pharmaceutical Practice, Centre Hospitalier Universitaire Sainte‐Justine, Montreal, Quebec, Canada;4. Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
Abstract:Flagellate dermatitis, a cutaneous eruption in which the patient appears to have been whipped, has been described with antineoplastic agents and shiitake mushroom ingestion. A 15‐year‐old girl with metastatic Ewing sarcoma developed pruritic erythematous linear lesions on her trunk that became hyperpigmented over time during her first cycle of chemotherapy with doxorubicin, vincristine, cyclophosphamide, and ganitumab. Flagellate dermatitis was diagnosed based on clinical and histologic findings. Flagellate dermatitis (FD) is a rare cutaneous eruption named for its appearance, in which the patient appears to have been whipped. It has been associated with chemotherapeutic agents such as bleomycin 1 . We report FD in a child that occurred during chemotherapy treatment that included doxorubicin.
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