Evaluation of [18F]FHPG as PET tracer for HSVtk gene expression |
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| Authors: | de Vries Erik F J van Dillen Ingrid J van Waarde Aren Willemsen Antoon T M Vaalburg Willem Mulder Nanno H Hospers Geke A P |
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| Affiliation: | PET Center, Groningen University Hospital, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. e.f.j.de.vries@pet.azg.nl |
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| Abstract: | In rats, the relationship between [(18)F]FHPG accumulation and HSVtk expression was studied with PET and autoradiography. [(18)F]FHPG distribution closely corresponded with HSVtk immunohistochemical staining. ROI analysis of tracer uptake 2 hours p.i. and Patlak graphical analysis were applied to quantify the PET data. For both analysis methods, the [(18)F]FHPG PET signal correlated well with the fraction of HSVtk expressing cells implanted, but showed a plateau when plotted against HSVtk protein levels. This might be due to rate limiting [(18)F]FHPG membrane transport. |
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