迁延性及慢性腹泻患儿血中胃泌素、胃动素和生长抑素水平

应用放免法测定 2 8例迁延性及慢性腹泻患儿治疗前、恢复期和 2 2例正常儿童的晨空腹及餐后 1h血中的胃泌素 (GAS)、胃动素 (MOT)和生长抑素 (SS)的水平 ,并进行相关分析。结果显示 :患儿治疗前、恢复期及对照组餐后血中的 GAS、MOT和 SS水平明显高于空腹时 (P<0 .0 1) ;治疗前空腹和餐后的血清 GAS、血浆 MOT水平及空腹的血浆 SS水平高于恢复期和对照组 (P<0 .0 5 ,0 .0 1) ,但餐后 SS水平无显著差异 (P>0 .0 5 ) ;患儿治疗前 GAS/SS和 MOT/ SS的比值增大 ,与恢复期和正常儿童比较差异极显著 (P<0 .0 5 ,0 .0 1)。恢复期和对照组血中 GAS与 SS和 MOT与 SS呈正相关 ,但治疗前则无相关。结果提示 ,腹泻迁延不愈可能与 GAS、 MOT和 SS分泌异常相关联

Determination of Blood Gastrin, Motilin and Somatostatin in the Children with Deferred or Chronic Diarrhea

The serum or plasma levels of gastrin (GAS), motilin (MOT) and somatostatin (SS) in 28 children with deferred or chronic diarrhea on an empty stomach and 1 h after having test breakfast, before treatment and at their recovery stages from illness were determined by radioimmunoassay and compared with those in 22 normal controls. The correlation analysis among the three gastrointestinal hormones were done respectively. The results showed that the serum or plasma levels of GAS, MOT and SS after having test breakfast were obviously higher than those on an empty stomach in the children with diarrhea before treatment, at their recovery stages and in normal controls ( P <0 01). The levels of serum GAS and plasma MOT before and after meal and the plasma levels of SS on an empty stomach in the children with diarrhea before treatment were higher than those at their recovery stages from illness and those of normal controls ( P <0 05, 0 01), but there was no significant difference in the plasma levels of SS after meal ( P >0 05). The values of GAS/SS and MOT/SS in the children with diarrhea before treatment were increased obviously with the difference being significant between those at their recovery stages from illness and those of normal controls ( P <0 05, 0 01). The positive correlation was found between GAS and SS and between MOT and SS in the children at their recovery stages from illness and in normal controls, but there was no correlation in children with diarrhea. The results indicated that the secretive disorders of GAS, MOT and SS may be the important factors causing diarrhea for a long time.