抑郁症首次发病患者静息态脑功能局部一致性的研究

目的 利用功能磁共振(fMRI)和局部一致性(regional homogeneity,ReHo)探讨抑郁症首次发病(以下简称首发)患者在静息态脑功能是否存在异常及异常部位.方法 对34例符合美国精神疾病诊断与统计手册第4版诊断标准的首发抑郁症患者(抑郁症组)和34名性别、年龄、文化程度匹配的健康志愿者(对照组)进行静息态fMRI扫描.结果 抑郁症组静息态脑血氧水平依赖信号的ReHo高于对照组的脑区有左侧额叶眶回、顶下小叶、颞上回,右侧额内侧回、顶下小叶、小脑后叶;低于对照组的脑区有左颞下回、右颞上同和胼胝体、双侧后扣带回(P＜0.005,K≥10).结论首发抑郁症患者在静息态存在多个腩区功能活动的异常,并可能和抑郁症的病理机制有关.

Resting state functional magnetic resonance imaging in patients with first-episode depression and control subjects

Objective To explore the abnormal brain activity during resting state in first-episode depressive patients with functional magnetic resonance imaging(fMRI)technique and regional homogeneity (ReHo)method.Methods Thirty-four patients with first-episode major depressive disorder and 34 gender-,age-,and education-matched normal controls received resting-state fMRI scans.Resting-state fMRI data were analyzed using the newly published ReHo approach.Results Compared with control subjects,the ReHo of blood oxygen level dependent signal of depressed patients showed increased in left frontal lobe,orbital-frontal gyri,superior frontal gyrus,middle frontal gyrus,right ventral frontal gyrus and posterior lobe of cerebellum bilateral inferior parietal lobe.On the other hand,decreased ReHo was found in left inferior temporal gyms,right superior temporal gyrus and bilateral posterior cingutate(P＜0.005,K≥10).Conclusion These results supported the abnormal resting-state brain activity in the early stage of MDD and misht be involved in the pathology of MDD.