GnRH gene expression in neuronal cell lines. |
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| Authors: | M E Wierman Z Fang J K Kepa |
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| Affiliation: | The Department of Medicine, University of Colorado Health Sciences Center; Denver, CO 80220, USA; Research Service, Veterans Affairs Medical Center; Denver, CO 80220, USA. |
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| Abstract: | Little is known about the mechanisms that subserve GnRH synthesis. The recent availability of clonal populations of GnRH neurons enables us for the first time to examine the structural organization of the GnRH locus. Studies are underway to dissect the manner in which neural specific expression and developmental regulation of GnRH are programmed. These studies will complement and provide direction to future animal studies designed to better understand the control of GnRH gene expression. |
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