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| 生长抑素在类固醇糖尿病大鼠胰腺中的表达 | |
| 引用本文： | 张芳林,叶传忠,张珍. 生长抑素在类固醇糖尿病大鼠胰腺中的表达[J]. 中国病理生理杂志, 2001, 17(10): 1005-1007 |
| 作者姓名： | 张芳林 叶传忠 张珍 |
| 作者单位： | 1. 福建医科大学附属协和医院,福建内分泌研究所,福建 福州 350001; 2. 福建医科大学附属协和医院,泌尿外科,福建 福州 350001 |
| 基金项目： | 福建省卫生厅青年基金资助项目(No. Q98-1-19) |
| 摘 要： | 目的:探讨不同剂量地塞米松(DEX)对大鼠胰岛细胞激素表达的影响。方法:雄性成年SD大鼠140只随机平均分成4组,应用放射免疫及原位杂交等技术观察不同剂量DEX作用下胰岛激素合成、储存及释放改变。结果:在一定范围内空腹血糖(FBG)、血清胰岛素(Ins)与DEX给药呈剂量及时间依赖性。胰腺中生长抑素(SS)的mRNA和蛋白表达以及血清中Ins水平的改变均早于FBG的升高。结论:DEX改变胰岛细胞Ins和SS的表达,这在类固醇糖尿病(SDM)发生过程中可能发挥重要作用。 |
| 关 键 词： | 糖尿病 地塞米松 胰岛素 生长抑素 |
| 文章编号： | 1000-4718(2001)10-1005-03 |
| 收稿时间： | 2000-04-05 |
| 修稿时间： | 2000-04-05 |
Somatostatin expression in rat islet of steroid diabetes mellitus ZHANG Fang-lin1, YE Chuan-zhong2, ZHANG Kai-zhen1 |
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| ZHANG Fang-lin ,YE Chuan-zhong ,ZHANG Kai-zhen. Somatostatin expression in rat islet of steroid diabetes mellitus ZHANG Fang-lin1, YE Chuan-zhong2, ZHANG Kai-zhen1[J]. Chinese Journal of Pathophysiology, 2001, 17(10): 1005-1007 | |
| Authors: | ZHANG Fang-lin YE Chuan-zhong ZHANG Kai-zhen |
| Affiliation: | 1. Fujian Institute of Endocrinology,Fujian Medical University,Fuzhou 350001, China; 2. Department of Urology, the Union Hospital, Fujian Medical University,Fuzhou 350001, China |
| Abstract: | AIM: To investigate the effects of dexamethasone(DEX) on the pancreatic endocrine function when steroid diabetes mellitus(SDM) occurred. METHODS: 140 rats were randomly assigned to 4 groups according to the clinic doses of DEX administration, Radioimmunoassay and in situ hybridization were applied to evaluate islet hormone changes in pancreas and blood.RESULTS: Changes in fasting blood glucose(FBG) 、fasting serum insulin(FINS) caused by DEX were dose and time-dependent. Changes in somatostatin(SS)mRNA and protein in islet as well as FINS occurred earlier than that of FBG. CONCLUSION: The super-physiological DEX influenced the expression SS and insulin secretion in islet, which may play an important role in SDM. |
| Keywords: | Diabetes mellitus Dexamethasone Insulin Somatostatin |
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