| 胸苷酸合成酶和二氢叶酸还原酶双抑制剂的研究进展 |
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| 引用本文： | 康从民,张德华,孙宗彬,王新宇.胸苷酸合成酶和二氢叶酸还原酶双抑制剂的研究进展[J].中国新药杂志,2010(2). |
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| 作者姓名： | 康从民 张德华 孙宗彬 王新宇 |
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| 作者单位： | 青岛科技大学化工学院; |
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| 基金项目： | 国家自然科学基金项目(20772070); 山东省自然科学基金(Y2007C175,Y2007C176); 山东省高等学校科技计划项目(J07YC08,J09LC20); 青岛市科技计划基础研究项目(09-1-3-74-JCH) |
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| 摘 要： | 胸苷酸合成酶和二氢叶酸还原酶在肿瘤、病菌的化学治疗中都是重要靶点,已有多种抑制剂应用于临床。近年来,随着对胸苷酸合成酶和二氢叶酸还原酶作用机制和抑制剂的耐药机制的不断阐明,人们设计和合成了一系列新的抑制剂,其中胸苷酸合成酶和二氢叶酸还原酶双抑制剂成为研究的热点之一。文中对胸苷酸合成酶和二氢叶酸还原酶抑制剂药物临床应用进行综述,并介绍胸苷酸合成酶和二氢叶酸还原酶双抑制剂的研究进展。
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| 关 键 词： | 胸苷酸合成酶 二氢叶酸还原酶 双抑制剂 |
Current status of dual inhibitors of thymidylate synthase and dihydrofolate reductase |
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| KANG Cong-min,ZHANG De-hua,SUN Zong-bin,WANG Xin-yu.Current status of dual inhibitors of thymidylate synthase and dihydrofolate reductase[J].Chinese Journal of New Drugs,2010(2). |
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| Authors: | KANG Cong-min ZHANG De-hua SUN Zong-bin WANG Xin-yu |
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| Institution: | KANG Cong-min,ZHANG De-hua,SUN Zong-bin,WANG Xin-yu (College of Chemical Engineering,Qingdao University of Science , Technology,Qingdao 266042,China) |
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| Abstract: | Both thymidylate synthase and dihydrofolate reductase are important targets in antitumor or antibacterial chemotherapy.A number of their inhibitors have been applied clinically.The mechanisms of the two enzymes and the resistance mechanisms of their inhibitors have been clarified,and a series of new inhibitors have been designed and synthesized.Especially,dual inhibitors of thymidylate synthase and dihydrofolate reductase have become a hotspot in research.This paper introduced the clinical application of th... |
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| Keywords: | thymidylate synthase dihydrofolate reductase dual inhibitor |
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