| 米托蒽醌聚乳酸缓释毫微粒冻干针剂的体外释药特性研究 |
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| 引用本文： | 徐超群,廖工铁,张志荣.米托蒽醌聚乳酸缓释毫微粒冻干针剂的体外释药特性研究[J].华西药学杂志,1998(4). |
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| 作者姓名： | 徐超群 廖工铁 张志荣 |
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| 作者单位： | 华西医科大学药学院!成都，610041，华西医科大学药学院!成都，610041，华西医科大学药学院!成都，610041 |
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| 摘 要： | 选择含1％维生素C的生理盐水作释药介质，用动态透析系统和分光光度法考察了不同分子量聚乳酸毫微粒冻干针剂的体外释药特性。高分子量聚乳酸毫微粒的释药速度明显慢于低分子量的聚乳酸毫微粒。通过选择适宜分子量的聚乳酸制备毫微粒可控制其释药速度。
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| 关 键 词： | 米托蒽醌聚乳酸缓释毫微粒 体外释药 动态透析系统 |
STUDY ON DRUG RELEASE FROM MITOXANTRONE POLYLACTIC ACID EXTENDED-RELEASE NANOPARTICLES IN VITRO |
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| Xu Chaoqun,Liao Gongtie,Zhang Zhirong.STUDY ON DRUG RELEASE FROM MITOXANTRONE POLYLACTIC ACID EXTENDED-RELEASE NANOPARTICLES IN VITRO[J].West China Journal of Pharmaceutical Sciences,1998(4). |
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| Authors: | Xu Chaoqun Liao Gongtie Zhang Zhirong |
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| Abstract: | Observed the rules of drug release from a liver targeting lyophilization injection mitoxantrone polylactic acid extended-release nanoparticles by dynamic penetration system and spectrophotometry in vitro. Following results were concluded.The release behavior of DHAQ from the NP was characteristically conformed to Higuchi square root law.The release speed is related to the molecular weight of PLA.The drug release equations from the low and high molecule PLA-NP are Q=-0. 046+ 0. 053,Q=0. 009+ 0. 033 respectively. For the low molecule PLA, the release speed is faster than that of the high molecule PLA. |
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| Keywords: | Mitoxantrone polylactic acid extended-release nanoparticle Drug-release in vitro Dynamic penetration system |
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