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Norditerpenoid alkaloids and other components from the processed tubers ofaconitum carmichaeli
Authors:Sang Hee Shim  So Young Lee  Ju Sun Kim  Kun Ho Son  Sam Sik Kang
Institution:Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Abstract:A new norditerpenoid and a known alkaloid were isolated from the alkaloidal fraction of the processed tubers of Aconitum carmichaeli. The structure of the new norditerpenoid alkaloid was elucidated as lipoforesaconitine (1) on the basis of spectroscopic analysis. The known norditerpenoid alkaloid was characterized as lipoyunanaconitine (2). In addition, a new flavonoid, 6"-O-acetylliquiritin (7), along with a known ceramide, (2S,3S,4R,8E)-2-(2'R)-2'-hydroxylignoceroylamino]-8(E)-octadecene-1,3,4-triol (3), as well as a known steroid saponin, gracillin (8), and three known flavonoids, liquiritigenin (4), isoliquiritigenin (5), and liquiritin (6), were also isolated and characterized. All known compounds were isolated from this plant for the first time. The structures of the isolates were established by spectroscopic and chemical methods.
Keywords:Prepared aconite            Aconitum carmichaeli            Ranunculaceae  Norditerpenoid alkaloid  Flavonoid  Steroid saponin
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