成骨诱导剂对拔牙创愈合的影响

目的 探讨以明胶海绵为载体,地塞米松、维生素C和β-甘油磷酸钠组成的成骨诱导剂对拔牙创愈合和牙槽嵴形态改建的影响。方法选用50只家兔,拔除双侧上颌第一前磨牙,右侧拔牙创内填入载有成骨诱导剂的明胶海绵,作为实验侧;左侧填入空载明胶海绵,作为对照侧。拔牙后第1、2、4、8、12周各处死10只动物,取双侧牙槽骨标本,拍摄X线片,并测量骨缺损区新骨密度;用组织学方法评价拔牙创愈合情况;并于12周时,测量拔牙区牙槽嵴高度吸收值。结果X线片骨密度测量显示：术后2、4、8、12周,实验侧骨密度值均高于对照侧,差异有统计学意义（P<0.01）。组织学检查显示：实验侧拔牙创内成骨现象较对照侧早,成骨细胞分化和增殖更活跃。
12周时实验侧牙槽嵴高度吸收值小于对照侧,差异有统计学意义（P<0.01）。结论 由地塞米松、β-甘油磷酸钠和维生素C组成的成骨诱导剂能促进拔牙创愈合,加速成骨和骨改建。

The effect of osteogenic inducer on healing of tooth extraction sockets

Objective To study the effect of osteogenic inducer(dexamethasone,β-sodium glycerophosphate and Vitamin C) carried by gelatin sponge on healing and remodeling of tooth extraction sockets.Methods Fifty rabbits were selected.After extracting the first premolars of bilateral maxillary,the right side tooth extraction sockets were filled with gelatin sponge containing osteogenic inducer as experimental side,tooth extraction sockets on left side were filled with gelatin sponge as control.Every ten rabbits were executed at the end of 1,2,4,8,12 weeks after tooth extraction.Bone density was measured through digital X-ray images.The specimens were examined by histology.The absorption height of alveolar bone at 12 weeks was measured.Results X-ray measurement showed that the bone den-sity of experimental side was higher than that of control side at 2,4,8,12 weeks,the difference had statistical sig-nificance(P<0.01).The histology examination showed that new bone formation in tooth extraction sockets of experimental side was earlier than that in control side.The absorptional height of alveolar bone had significant difference between experimental side and control side(P<0.01),of which experimental side was less.Conclusion Filling the osteogenic inducer in tooth extraction sockets can promote the healing and new bone formation and prevent from al-veolar bone absorption.