| 一氧化氮对舌下神经核兴奋作用的影响 |
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| 引用本文： | Wu H,Liu H,Horner RL,Liu L. 一氧化氮对舌下神经核兴奋作用的影响[J]. 华西口腔医学杂志, 2012, 30(3): 317-320. DOI: 10.3969/j.issn.1000-1182.2012.03.023 |
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| 作者姓名： | Wu H Liu H Horner RL Liu L |
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| 作者单位： | 1.昆明医学院第二附属医院耳鼻喉科, 昆明650101;2.多伦多大学医学生理学系, 加拿大安大略M5S 1A8; 3.昆明医学院第一附属医院整形外科, 昆明650032 |
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| 摘 要： | 目的观察一氧化氮（NO）及其清除剂对舌下神经运动核（HMN）活动的影响并初步探讨其机制。方法麻醉雄性成年Wistar大鼠,微透析探针先透析人工脑脊液（ACSF）到HMN作为对照,然后再分别持续给予二乙胺一氧化氮水合钠盐（DEA,NO供体）和2-（4-羧基苯基）-4,4,5,5,-四甲基-1,3-二氧咪唑啉钾盐（carboxy-PTIO,NO清除剂）到HMN,观测大鼠颏舌肌（GG）、膈肌电活动及血压和呼吸频率的变化。结果给予DEA后,大鼠的呼吸相关GG活动明
显增加,而给予carboxy-PTIO后则明显降低,与ACSF时的值相比差异均有统计学意义（P<0.05）。不管是给予DEA还是carboxy-PTIO,在30~120 min时大鼠的紧张性GG活动、膈肌活动、血压及呼吸频率与ACSF时的值相比均无统计学差异（P>0.05）。结论NO作为一种神经递质对HMN产生兴奋,从而对维持生理状态下上气道的开放起重要作用。
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| 关 键 词： | 一氧化氮 舌下神经核 神经递质 颏舌肌 阻塞性睡眠呼吸暂停综合征 |
| 收稿时间： | 2012-06-25 |
| 修稿时间： | 2012-06-25 |
Nitric oxide acts as an excitatory neurotransmitter at hypoglossal motor nucleus |
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| Wu Haiying,Liu Hattie,Horner Richard L,Liu Liu. Nitric oxide acts as an excitatory neurotransmitter at hypoglossal motor nucleus[J]. West China journal of stomatology, 2012, 30(3): 317-320. DOI: 10.3969/j.issn.1000-1182.2012.03.023 |
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| Authors: | Wu Haiying Liu Hattie Horner Richard L Liu Liu |
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| Affiliation: | 1. Dept. of Otolaryngology, The Second Affiliated Hospital of Kunming Medical University,Kunming 650101, China; 2. Dept. of Medicine and Physiology, University of Toronto, Ontario M5S 1A8, Canada;3. Dept. of Plastic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China |
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| Abstract: | Objective The study is to observe the effect of nitric oxide(NO) donor and scavenger to the hypoglossal motor nucleus(HMN) activity and explore the underlying mechanism.Methods Male adult anesthetized Wis-tar rats were anesthetized.The activity of genioglossus(GG),diaphragma,blood pressure(BP) and respiratory rate(RR) were recorded when constant microdialysis perfusion of artificial cerebrospinal fluid(ACSF) to HMN as control,followed with diethylamine NONOate sodium salt hydrate(DEA),a NO donor,and 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt(carboxy-PTIO),a NO scavenger.Results Compared with ACSF, application of DEA and carboxy-PTIO at HMN increased and decreased the GG activity respectively and significantly(P<0.05),mainly respiratory-related activity.The tonic GG,diaphragma activity,BP and RR had not been affected statistically between 30-120 min when microdialysis perfusion of both DEA and carboxy-PTIO were delivered.Con-clusion Acting as an excitatory neurotransmitter of HMN,NO may contribute to the patency of upper airway phy-siologically. |
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| Keywords: | nitric oxide hypoglossal motor nucleus neurotransmitter genioglossus obstructive sleep apnea-hypopnea syndrome |
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