Effect of L-NAME on the synthesis of plasma fibrinogen in mice |
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Authors: | Takinishi Yasutaka Okazaki Masako Oguchi Katsuji |
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Institution: | Department of Pharmacology, Showa University School of Medicine, Tokyo 142-8555, Japan. |
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Abstract: | The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral N(G)-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the alpha- and beta-chains of fibrinogen, whereas plasma NO(2)(-) level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase. |
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