| 凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究 |
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| 引用本文： | 王玲玲,席玉玲,凌斌,赵卫东,承泽农.凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究[J].蚌埠医学院学报,2011,36(3):223-226. |
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| 作者姓名： | 王玲玲 席玉玲 凌斌 赵卫东 承泽农 |
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| 作者单位： | 1. 安徽医科大学附属省立医院 妇产科, 安徽 合肥 230032;2. 蚌埠医学院第一附属医院 妇产科, 安徽 蚌埠 233004;3. 蚌埠医学院 病理学教研室, 安徽 蚌埠 233030 |
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| 摘 要： | 目的: 探讨Livin和张力蛋白同源10q丢失的磷酸酶基因(phosphatase and tensin hornology deleted on chromosome 10,PTEN)的表达与卵巢上皮性癌的临床病理学特征的关系及其相关性。方法: 采用免疫组织化学EliVision法检测60例卵巢上皮性癌组织、20例良性卵巢上皮性肿瘤及20例正常卵巢组织中Livin及PTEN表达情况。结果: 卵巢上皮性癌中Livin阳性率(80.0%)均明显高于卵巢良性上皮性肿瘤(10.0%)及正常卵巢组织(5.0%)(P<0.01)。卵巢上皮性癌的组织病理学分级间Livin的阳性率差异有统计学意义(P<0.01),而在临床分期及淋巴结转移中差异均无统计学意义(P>0.05)。卵巢上皮性癌中PTEN的阳性率(26.7%)均明显低于卵巢良性上皮性肿瘤(95.0%)及正常卵巢组织(100.0%)(P<0.01);卵巢上皮性癌的临床分期、组织病理学分级及淋巴结有无转移间PTEN的阳性率差异均有统计学意义(P<0.01)。卵巢上皮性癌中Livin的阳性率与PTEN的阳性率呈负相关关系(P<0.01)。结论: Livin的表达上调及PTEN的表达下调在卵巢上皮性癌的发生、分化进展中起重要作用,Livin基因有可能成为治疗卵巢癌的新靶点。
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| 关 键 词： | 卵巢肿瘤 凋亡抑制基因 表达 病理学 相关性 |
| 收稿时间： | 2010-12-03 |
Relationship of expression of apoptosis inhibitor gene Livin and cancer surppresser gene PTEN in epithelial ovarian carcinoma |
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| WANG Ling-ling,XI Yu-ling,LING Bin,ZHAO Wei-dong,CHENG Ze-nong.Relationship of expression of apoptosis inhibitor gene Livin and cancer surppresser gene PTEN in epithelial ovarian carcinoma[J].Journal of Bengbu Medical College,2011,36(3):223-226. |
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| Authors: | WANG Ling-ling XI Yu-ling LING Bin ZHAO Wei-dong CHENG Ze-nong |
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| Institution: | 1. Department of Obstetrics and Gynecology, Anhui Provinical Hospital, Anhui Medical University, Hefei Anhui 230032;2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;3. Department of Pathology, Bengbu Medical College, Bengbu Anhui 233030, China |
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| Abstract: | Objective:To study the expression and pathological characteristics of Livin and PTEN proteins in epithelial ovarian carcinoma as well as their inter-relationship. Methods:The Expression of Livin and PTEN in 60 samples of ovarian epithelial carcinoma,20 samples of benign ovarian epithelial tumor and 20 normal ovarian tissues were detected by immunohistochemistry. Results:The Livin protein expression(80.0%) in epithelial ovarian carcinoma tissues was significantly higher than that of benign ovarian epithelial... |
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| Keywords: | ovarian neoplasmas apoptosis inhibitor gene expression pathological correlation |
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