Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey |
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Authors: | Matthias Boentert Rainer Dziewas Anna Heidbreder Svenja Happe Ilka Kleffner Stefan Evers Peter Young |
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Institution: | 1. Department of Neurology, University Hospital Münster, Albert-Schweitzer-Str. 33, 48129, Münster, Germany 2. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of G?ttingen, Züricher Strasse 40, 28325, Bremen, Germany
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Abstract: | To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a
large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL).
Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional
Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS
was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36
questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult
self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to
78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse
sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often
and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS
severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced
in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for
CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life. |
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