血清胆红素和尿酸联合评价冠状动脉病变的研究

目的：研究以血清胆红素与尿酸联合评价冠状动脉病变的价值。方法：经冠脉造影证实的冠心病患者258例（冠心病组），选择同期经过冠脉造影排除冠心病的88例为对照组。冠心病组又分为单支病变组（86例）、双支病变组（89例）和多支病变组（83例）三个亚组，检测各组血尿酸、胆红素及血脂水平，并进行比较分析。结果：与对照组比较，冠心病组总胆红素（21．43±5．67）μmol／L比（15．51±7．61）μmol／L]、间接胆红素（19．20±5．37）μmol／L比（12．94±5．63）μmol／L]水平明显降低（P〈O．05），血清尿酸（301．55士78．36）μmol／L比（359．73±97．67）μmol／L]、总胆固醇（4．01±0．74）mmol／L比（5．07±1．87）mmol／L]、甘油三酯（1．86±1．07）mmol／L比（2．03±2．41）mmol／L]及低密度脂蛋白胆固醇（2．42±0．56）mmol／L比（3．14±1．21）mmol／L]水平明显升高（P〈0．05～〈0．01），且冠心病各亚组上述指标水平与对照组均有类似显著差异（P〈0．05～〈0．01）。结论：血清尿酸水平的升高和／或胆红素水平的降低与冠心病发生、发展相关。

Study evaluting coronary artery lesion by serum bilirubin and uric acid

Objective： To investigate the value evaluting coronary artery lesion by serum bilirubin and uric acid （UA）. Methods： According to results of coronary angiography, a total of 258 patients with coronary heart disease （CHD） were enrolled as CHD group, and another 88 non-CHD subjects were regard as control group. CHD group was further divided into single-vessel coronary disease group （n = 86）, double -vessel coronary disease group （n = 89） and multi--vessel coronary disease group （n=83）. Levels of serum UA, bilirubin and blood lipids were measured, compared among analyzed among all groups. Results： Compared with control group, there were significant decrease in levels of total bilirubin （21.43＋5.67） μmol/L vs. （15.51＋7.61）μmol/L] and indirect bilirubin F （19.20＋5.37） μmol/L vs. （12.94＋5.63） μmol/L, P〈0.05 both], and significant increase in serum UA E（301.55＋78.36）μmol/ L vs. （359.73＋97.67） μmol/L], total cholesterol （4.01＋0.74） mmol/L vs. （5.07＋1.87） mmol/L], triglycer- ide E （1.86＋ 1.07） mmol/L vs. （2.03＋2.41） mmol/L] and low density lipoprotein-cholesterol F （2.42＋0.56） mmol/L vs. （3.14＋1.21） mmol/L] in CHD group, P〈0.05〈0.01. There were similar significant difference in above indicators between each creased level of serum bilirubin subgroup of CHD group and control group （P〈0.05-〈0.01）. Conclusion： Deand/or increased level of serum uric acid are related to occurrence and development of coronary heart disease.