| 高效液相色谱法测定珍珠滴丸中甘草酸含量 |
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| 引用本文： | 杨先炯,王爱民,李勇军,兰燕宇,何迅,王永林. 高效液相色谱法测定珍珠滴丸中甘草酸含量[J]. 中国药业, 2008, 17(3): 12-13 |
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| 作者姓名： | 杨先炯 王爱民 李勇军 兰燕宇 何迅 王永林 |
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| 作者单位： | 贵阳医学院,贵州,贵阳,550004 |
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| 基金项目： | 贵州省中药现代化科技产业研究开发专项项目 |
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| 摘 要： | 目的建立珍珠滴丸中甘草酸含量的测定方法。方法采用Hypersil C18柱（150mm×4.6mm，μm），流动相为乙腈-1％乙酸（33：67），检测波长为250nm，流速为1．0mL／min，柱温40℃。结果甘草酸的进样量线性范围为0．41～1．2μg，r=0、9999（n=5），平均回收率为99．92％，RSD为1．71％（n=6）。结论该方法灵敏度高、准确、快捷，结果可靠，可作为珍珠滴丸的质量控制方法。
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| 关 键 词： | 珍珠滴丸 甘草酸 高效液相色谱法 含量测定 |
| 文章编号： | 1006-4931（2008）03-0012-02 |
| 收稿时间： | 2007-07-24 |
| 修稿时间： | 2007-10-11 |
Determination of Glycyrrhizic Acid in Pearl Dropping Pills by HPLC |
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| Yang Xianjiong,Wang Aimin,Li Yongjun,Lan Yanyu,He Xun,Wang Yonglin. Determination of Glycyrrhizic Acid in Pearl Dropping Pills by HPLC[J]. China Pharmaceuticals, 2008, 17(3): 12-13 |
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| Authors: | Yang Xianjiong Wang Aimin Li Yongjun Lan Yanyu He Xun Wang Yonglin |
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| Affiliation: | (School of Pharmacy, Guiyang Medical College, Guiyang, Guizhou, China 550004) |
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| Abstract: | Objective To establish a HPLC method for the determination of glycyrrhizic acid in Pearl Dropping Pill. Methods The separation was performed on Hypersil-C18 column with acetonitrile-1.0% acetic acid （33：67）, The detection wavelength was at 250 nm with the flow rate of 1, 0 mL/min, The column temperature was 40℃, Results The linear range of glycyrrhizic acid was 0.41 - 1. 2 μg. The average recovery rate was 99, 92% ,and RSD was 1.71%. Conclusion The method is accurate and reliable with a high sensitivity,which can be the foundation for the quality evaluation of Pearl Dropping Pill. |
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| Keywords: | Pearl Dropping Pill glycyrrhizic acid HPLC content determination |
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