Abstract: | Aortic valve replacement using human allograft valves is a well established procedure, following which histological evidence of a host-graft interaction is seen .This varies in intensity, depending on the types of sterilizing and storage agents to which the allograft is exposed prior to insertion. A canine experimental model which enables study of these tissue ingrowth patterns in variously treated allografts has been devised. The technique is described in detail. |