Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells |
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Authors: | Rodgers Allison K Nair Anitha Binkley Peter A Tekmal Rajeshwar Schenken Robert S |
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Affiliation: | Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas 78229, USA. |
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Abstract: | The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions. |
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