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Extraskeletal myxoid chondrosarcoma: a study using a quick-freezing and deep-etching method
Authors:Akihiro Hemmi  Shunzo Osaka  Keishin Sunagawa  Kentaro Kikuchi  Nobuhiko Ohno  Nobuo Terada  Yasuhisa Fujii  Shinichi Ohno  Norimichi Nemoto
Affiliation:1. Department of Pathology, Nihon University, Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo, 179-0072, Japan
2. Department of Orthopedic Surgery, Nihon University Nerima, Hikarigaoka Hospital, Tokyo, Japan
5. Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
3. Department of Anatomy, Interdisciplinary Graduate School, University of Yamanashi, Yamanashi, Japan
4. Department of Rehabilitation Sciences, Teikyo University of Science & Technology, Yamanashi, Japan
Abstract:A case of extraskeletal myxoid chondrosarcoma (ESMC), which developed in the right thigh of a middle-aged Japanese woman, was studied using immunohistochemistry, conventional electron microscopy, and the quick-freezing and deep-etching (QF-DE) method. In addition to typical light microscopic findings of ESMC, conventional electron microscopy indicated that the tumor cells had features of chondrocytes. Immunohistochemically, the tumor cells showed a positive immunoreaction for S100 protein. A diagnosis of ESMC was made. An interesting observation was the ultrastructural features of collagen fibrils in the myxoid matrix highlighted by the QF-DE method. These collagen fibrils consisted of relatively thin collagen (20–35 nm) with pleated surface structures. The surface striation at 65 nm was obscure. We consider that such a finding of collagen fibrils identified by the QF-DE method is one of the characteristics of the myxoid matrix of ESMC, and this is useful for the differential diagnosis of myxoid soft tissue tumors.
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