伏核注射促甲状腺素释放激素对大鼠丘脑束旁核痛放电的影响

<正> 近年来大量实验表明,广泛分布于中枢神经系统的促甲状腺素释放激素(TRH)参与多种生理功能的调节。脑室微量注射TRH,可提高小鼠的痛阈,提示TRH可能参与中枢镇痛过程、伏核、杏仁核及尾核是针刺镇痛和痛觉调制中的重要结构。免疫

EFFECT OF INJEClTION OF THYROTROPIN—RELEASING HORMONE INTO NUCLEUS ACCUMBENS ON THE PAIN DISCH—ARGES IN NUCLEUS PARAFASCI—CULARIS OF RAT-THALAMUS

Glass microelectaod recording method was used to investigate the effect of thyrotropin-releasing hormone(TRH) into nucleus accumbens, nucleus amygdaloid or nucleus caudate-putamen on unit discharges of pain-excitation neurons (PEN) in nucleus parafascicularis of thalamus in rats. The results showed that: (1) TRH injccted into the nucleus accumbens results in a significant ihhibition of pa- in discharges of PEN in nucleus parafascicularis. But injection of TRH into nuc- leus amygdaloid, nucleus caudate-putamen had no significant effect. (2) Pretreat- ment with auropine abolished the inhibitory effect of TRH. (3)'Pretaeatment with haloperidol also adolished the inhibitory effect of TRH. (4) Pretaeatment with naloxone, propranolol or phen-tolamine did not affect the inhibitory effect of TRH. The results mentioned above suggested that nucleus accumbens could be a sp- ecial area in response to TRH and the effect of TRH seems to be involved in both cholinergic M-receptor and dopamine receptor.