| HPLC测定扎托布洛芬缓释胶囊的含量 |
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| 引用本文： | 余凤玮,孙逊,张彦,刘福,龚涛,张志荣. HPLC测定扎托布洛芬缓释胶囊的含量[J]. 华西药学杂志, 2012, 27(3): 330-331 |
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| 作者姓名： | 余凤玮 孙逊 张彦 刘福 龚涛 张志荣 |
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| 作者单位： | 余凤玮 (四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都,610041) ； 孙逊 (四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都,610041) ； 张彦 (重庆药友制药有限公司研发中心,重庆,601121) ； 刘福 (川北医学院附属医院药剂科,四川南充,637000) ； 龚涛 (四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都,610041) ； 张志荣 (四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都,610041) |
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| 摘 要： | 目的采用HPLC法测定扎托布洛芬缓释胶囊的含量。方法采用Kromasil C18(150 mm×4.6 mm,5μm)色谱柱,流动相为乙腈-水-冰醋酸(300∶200∶1),流速1.0 mL·min-1,检测波长240 nm。结果 5～35μg·mL-1扎托布洛芬与峰面积呈良好的线性关系(r=0.9999),平均回收率为99.03%,RSD=0.52%。结论所用方法准确可靠,简便,快速,适用于扎托布洛芬缓释胶囊的质量控制。
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| 关 键 词： | 扎托布洛芬缓释胶囊 含量测定 高效液相色谱法 |
Determination of the content of Zaltoprofen sustained-release capsules by HPLC |
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| YU Feng-wei,SUN Xun,ZHANG Yan,LIU Fu,GONG Tao,ZHANG Zhi-rong. Determination of the content of Zaltoprofen sustained-release capsules by HPLC[J]. West China Journal of Pharmaceutical Sciences, 2012, 27(3): 330-331 |
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| Authors: | YU Feng-wei SUN Xun ZHANG Yan LIU Fu GONG Tao ZHANG Zhi-rong |
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| Affiliation: | 1(1.Key Laboratory of Drug Targeting and Drug Delivery Systems,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China;2.R&D Center,Yaopharma Co.,Ltd.,Chongqing,601121 P.R.China;3.Department of Pharmacy,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan,637000 P.R.China) |
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| Abstract: | OBJECTIVE To develop an HPLC method for determination of the content of Zaltoprofen(ZP) sustained-release capsules.METHODS Chromatographic conditions included a Kromasil C18 column(150 mm×4.6 mm,5 μm),and the mobile phase consisted of acetonitrile-water-acetic acid(300:200:1).The flow rate was 1.0 mL·min-1,and the detective wavelength was 240 nm.RESULTS The good linear relationship was within the range of 5~35 μg·mL-1(r=0.9999).The average recovery of ZP was 99.03%(RSD=0.52%).CONCLUSION The method is accurate,simple,and rapid.It can be used to determine the content of ZP sustained-release capsules. |
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| Keywords: | Zaltoprofen sustained-release capsules Content determination HPLC |
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