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| 汉坦病毒重组蛋白检测血清中特异性IgA、IgM抗体的动态变化 | |
| 引用本文： | 陈宇萍,安丽敏,牛聪敏,耿志州,郭彦敏,王丽英,马士恒,孟祥芝. 汉坦病毒重组蛋白检测血清中特异性IgA、IgM抗体的动态变化[J]. 中国医药导报, 2007, 4(17): 13-15 |
| 作者姓名： | 陈宇萍 安丽敏 牛聪敏 耿志州 郭彦敏 王丽英 马士恒 孟祥芝 |
| 作者单位： | 1. 保定市传染病医院,河北保定,071000 2. 河北大学附属医院,河北保定,071000 3. 中国疾病预防控制中心病毒病预防控制所,北京,100088 |
| 基金项目： | 河北省自然科学基金资助项目(04276101D-89) |
| 摘 要： | 目的:探讨重组蛋白检测血清中特异性IgA、IgM抗体的动态变化。方法:用杆状病毒表达的汉坦病毒重组核蛋白(rNP)和糖蛋白(rGP)为抗原,检测14例61份急性期SEO型病人系列血清中的特异性IgA、IgM,寻找HFRS病人IgA、IgM抗体的动态变化规律。结果:几乎所有HFRS病人早期即有强烈的IgA、IgM应答,尤其是针对rNP的抗体出现早且滴度高,抗rGP出现亦早,但滴度偏低。结论:应用rNP和rGP为抗原,在发病早期检测IgM的同时,检测I-gA,可以起到互补的作用,特别是对HFRS早期临床表现不典型的病例。 |
| 关 键 词： | 汉坦病毒 血清IgA抗体 临床诊断 |
Development of hantavirus glycocapsid proteins special IgA,IgM of serum in hemorrhagic fever with renal syndrome patients |
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| CHEN Yu-pin,AN Li-min,NIU Cong-min,GENG Zhi-zhou,GUO Yan-min,WANG Li-ying,MA Shi-heng,MENG Xiang-zhi. Development of hantavirus glycocapsid proteins special IgA,IgM of serum in hemorrhagic fever with renal syndrome patients[J]. China Medical Herald, 2007, 4(17): 13-15 | |
| Authors: | CHEN Yu-pin AN Li-min NIU Cong-min GENG Zhi-zhou GUO Yan-min WANG Li-ying MA Shi-heng MENG Xiang-zhi |
| Affiliation: | CHEN Yu-ping1,AN Li-min2,NIU Cong-min1,GENG Zhi-zhou1,GUO Yan-min1,WANG Li-ying1,MA Shi-heng2,MENG Xiang-zhi3 |
| Abstract: | Objective:To examine glycocapsid proteins special IgA,IgM of serum in hemorrhagic fever with renal syndrome patients.Methods:Nnucleocapsid and glycocapsid proteins were produced as diagnostic antigens to test 61 serial serum samples from 14 cases during the acute phase.Results:An early and strong IgA,IgM humoral response was observed in almost of all HFRS cases. The titer of antibody to NP was higher than that of GP.Conclusion:These results showed a clue that Nnucleocapsid and glycocapsid proteins special IgA maybe play a role in the diagnisis of HFRS,used together with IgM especially in which the course of infection is atypical. |
| Keywords: | Hantavirus IgA antibodies in serum Clinical diagnosis |
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