|
|||||
|
|
| 治咳川贝枇杷滴丸中薄荷脑大鼠体内药物动力学及体内外相关性研究 | |
| 引用本文： | 杨彬,刘丹,杜超,王金磊,王丽峰,王阳,刘俊静. 治咳川贝枇杷滴丸中薄荷脑大鼠体内药物动力学及体内外相关性研究[J]. 中国中药杂志, 2013, 38(9): 1421-1425 |
| 作者姓名： | 杨彬 刘丹 杜超 王金磊 王丽峰 王阳 刘俊静 |
| 作者单位： | 1. 天津中医药大学中药学院,天津,300193 2. 天津中新药业集团股份有限公司第六中药厂,天津,300401 3. 天津中医药大学中药学院,天津300193;天津中医药大学实验教学部,天津300193 |
| 摘 要： | 该研究采用气相色谱(GC)法测定大鼠单剂量给药治咳川贝枇杷滴丸(ZCPDP)及不同剂量薄荷脑药材后血浆中薄荷脑的浓度,通过DAS 3.1.6软件计算药动学参数；采用Loo-Riegelman法计算体内累积吸收百分率,并与体外累积释放百分率进行线性回归,考察体内外相关性.结果显示ZCPDP中薄荷脑在大鼠体内药动学行为符合二房室模型特征,主要参数tmax为10 min,t1/2β为(183.93 +52.75) min,CL/F为(0.426+0.194)L·min-1·kg-1,均与等剂量药材药动学参数无差异；不同剂量薄荷脑药材主要参数tmax,t1/2β,CL/F有显著差异(P＜0.05),且AUC0-∞与给药剂量不成正比.ZCPDP累积吸收率对累积释放率回归方程为Fa=1.160 3Q-19.968(r =0.981 3).实验结果表明ZCPDP中薄荷脑与等剂量薄荷脑药材在大鼠体内有相似的药动学行为,同时具有良好的体内外相关性；在19.2～570 mg·kg-1,薄荷脑在大鼠体内动力学过程存在显著性差异. |
| 关 键 词： | 治咳川贝枇杷滴丸(ZCPDP) 薄荷脑 药物动力学 体内外相关性 |
| 收稿时间： | 2013-01-03 |
Study on pharmacokinetics and in vitro/in vivo correlation of menthol in Zhike Chuanbei Pipa dropping pills in rats |
|
| YANG Bin,LIU Dan,DU Chao,WANG Jin-lei,WANG Li-feng,WANG Yang and LIU Jun-jing. Study on pharmacokinetics and in vitro/in vivo correlation of menthol in Zhike Chuanbei Pipa dropping pills in rats[J]. China Journal of Chinese Materia Medica, 2013, 38(9): 1421-1425 | |
| Authors: | YANG Bin LIU Dan DU Chao WANG Jin-lei WANG Li-feng WANG Yang LIU Jun-jing |
| Affiliation: | College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;No. 6 Traditional Chinese Medicines Factory of Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300401, China;College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;No. 6 Traditional Chinese Medicines Factory of Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300401, China;College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Experimental Teaching Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Experimental Teaching Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;No. 6 Traditional Chinese Medicines Factory of Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300401, China |
| Abstract: | |
| Keywords: | Zhike Chuanbei Pipa dropping pills (ZCPDP) menthol pharmacokinetics in vitro/in vivo correlation |
| 本文献已被 万方数据 等数据库收录！ | |