| 十一酸睾酮醇质体制备及其体外经皮渗透研究 |
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| 引用本文： | 孟舒,杨立群,马丽颖,郭晶,李淼,杨丹. 十一酸睾酮醇质体制备及其体外经皮渗透研究[J]. 中国中药杂志, 2013, 38(9): 1371-1374 |
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| 作者姓名： | 孟舒 杨立群 马丽颖 郭晶 李淼 杨丹 |
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| 作者单位： | 1. 辽宁省计划生育研究院,辽宁沈阳,110031
2. 辽宁中医药大学,辽宁沈阳,110032 |
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| 基金项目： | 辽宁省博士科研启动基金项目(20091036) |
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| 摘 要： | 醇质体作为透皮给药的新载体,能明显促进药物的经皮渗透,该文以十一酸睾酮为主药,制备十一酸睾酮醇质体并对其形态、粒径、包封率、膜的流动性进行测定,同时以小鼠皮肤进行体外透皮实验,考察醇质体作为十一酸睾酮经皮给药载体的渗透特性,并比较了十一酸睾酮醇质体、脂质体及其醇溶液中的透皮行为.
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| 关 键 词： | 十一酸睾酮 醇质体 经皮渗透 |
| 收稿时间： | 2012-12-18 |
Study on preparation of testosterone undecanoate ethosomes and its in vitro transdermal penetration |
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| MENG Shu,YANG Li-qun,MA Li-ying,GUO Jing,LI Miao and YANG Dan. Study on preparation of testosterone undecanoate ethosomes and its in vitro transdermal penetration[J]. China Journal of Chinese Materia Medica, 2013, 38(9): 1371-1374 |
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| Authors: | MENG Shu YANG Li-qun MA Li-ying GUO Jing LI Miao YANG Dan |
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| Affiliation: | Liaoning Institute of Family Planning, Shenyang 110031, China;Liaoning Institute of Family Planning, Shenyang 110031, China;Liaoning Traditional Chinese Medicine University, Shenyang 110032, China;Liaoning Institute of Family Planning, Shenyang 110031, China;Liaoning Institute of Family Planning, Shenyang 110031, China;Liaoning Institute of Family Planning, Shenyang 110031, China |
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| Abstract: | Ethosomes, as a new vector for transdermal drug delivery, could obviously improve the transdermal penetration of drugs.In this study, we prepared testosterone undecanoate ethosomes, with TU ethosomes as the basic remedy, to determine its appearance, particle size, entrapment efficiency (EE) and membrane fluidity.Meanwhile, a transdermal test was conducted in mice, in order to determine the permeability characteristics of ethosomes as a vector for transdermal drug delivery, and compare transdermal behaviors of TU ethosomes, liposomes and their ethanol solutions. |
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| Keywords: | testosterone undecanoate ethosomes transdermal permeability |
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