| 女贞子化学成分研究 |
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| 引用本文： | 张廷芳,戴毅,屠凤娟,姚新生.女贞子化学成分研究[J].中国药房,2011(31):2931-2933. |
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| 作者姓名： | 张廷芳 戴毅 屠凤娟 姚新生 |
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| 作者单位： | 暨南大学中药及天然药物研究所;广东省中药药效物质基础及创新药物研究重点实验室;沈阳药科大学; |
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| 基金项目： | 深圳市基础研究计划项目(JC200903170506A) |
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| 摘 要： | 目的:研究女贞子的化学成分。方法:采用硅胶、反相ODS、Sephadex LH-20、反相HPLC等色谱分离手段对女贞子乙酸乙酯萃取部位进行分离纯化,通过ESI-MS、NMR等波谱技术和化学方法鉴别所分离得到化合物的结构。结果:从中分离得到8个化合物,分别鉴定为:齐墩果酸(oleanolic acid,1)、2α-羟基齐墩果酸(2α-hydroxy oleanolic acid,2)、19α-羟基-乌苏酸(19α-hydroxy ursolic acid,3)、委陵菜酸(tormentic acid,4)、3β-O-顺式-香豆酰-2α-羟基-齐墩果酸3β-O-(cis-p-Coumaroyl)-2α-hydroxy oleanolic acid,5]、3β-O-反式-香豆酰-2α-羟基-齐墩果酸3β-O(-trans-p-Coumaroyl)-2α-hydroxy oleanolic acid,6]、3-O-顺式-香豆酰-委陵菜酸(3-O-cis-p-Coumaroyl tormentic acid,7)、3-O-反式-香豆酰-委陵菜酸(3-O-trans-p-Coumaroyl tormentic acid,8)。结论:化合物3、5、7、8为首次从该属植物中分离得到。
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| 关 键 词： | 女贞子 化学成分 结构鉴定 |
Chemical Constituents of Ligustrum lucidum |
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| ZHANG Ting-fang,DAI Yi,YAO Xin-sheng DAI Yi TU Feng-juan,YAO Xin-sheng.Chemical Constituents of Ligustrum lucidum[J].China Pharmacy,2011(31):2931-2933. |
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| Authors: | ZHANG Ting-fang DAI Yi YAO Xin-sheng DAI Yi TU Feng-juan YAO Xin-sheng |
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| Institution: | ZHANG Ting-fang,DAI Yi,YAO Xin-sheng(Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China) DAI Yi(Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,China) TU Feng-juan,YAO Xin-sheng(Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | OBJECTIVE：To study the chemical constituents of Ligustrum lucidum.METHODS：Isolation and purification were carried out by column chromatography over silica gel,RP-ODS,Sephadex LH-20 and RP-HPLC.The chemical constituents were identified by ESI-MS and NMR.RESULTS：Eight compounds were identified as oleanolic acid（1）,2α-hydroxy-oleanolic acid（2）,19α-hydroxy ursolic acid（3）,tormentic acid（4）,3β-O-（cis-p-Coumaroyl）-2α-hydroxy oleanolic acid（5）,3β-O-（trans-p-Coumaroyl）-2α-hydroxy oleanolic acid（6）,3-O-cis-p-Coumaroyl tormentic acid（7）,3-O-trans-p-Coumaroyl tormentic acid（8）.CONCLUSION：Compounds 3,5,7,8 are isolated from this genus for the first time. |
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| Keywords: | Ligustrum lucidum Chemical constituents Structure identification |
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