Effects of barrier-induced nuclear spin magnetization inhomogeneities on diffusion-attenuated MR signal. |
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Authors: | A L Sukstanskii J J H Ackerman D A Yablonskiy |
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Affiliation: | Department of Radiology, Washington University, St. Louis, Missouri 63110, USA. alex@wuchem.wustl.edu |
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Abstract: | The spatial distribution of the transverse nuclear spin magnetization, appearing in a single compartment with impermeable boundaries in a Stejskal-Tanner gradient pulse MR experiment, is analyzed in detail. At short diffusion times the presence of diffusion-restrictive barriers (membranes) reduces effective diffusivity near the membranes and leads to an inhomogeneous spin magnetization distribution (the edge-enhancement effect). In this case, the signal reveals a quasi-two-compartment behavior and can be empirically modeled remarkably well by a biexponential function. The current results provide a framework for interpreting experimental MR data on various phenomena, including water diffusion in giant axons, metabolite diffusion in the brain, and hyperpolarized gas diffusion in lung airways. |
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Keywords: | diffusion magnetic resonance MRI CNS diffusion imaging |
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