| 脾切除对晚期血吸虫病患者细胞免疫调节失常的影响 |
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| 引用本文： | 马北阳,桂稀恩,杨自成,熊勇,王厚成,汪正柄. 脾切除对晚期血吸虫病患者细胞免疫调节失常的影响[J]. 中国寄生虫学与寄生虫病杂志, 1993, 0(4) |
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| 作者姓名： | 马北阳 桂稀恩 杨自成 熊勇 王厚成 汪正柄 |
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| 作者单位： | 湖北医学院附属第二医院，湖北医学院附属第二医院，湖北医学院附属第二医院，湖北医学院附属第二医院，湖北省江陵县血吸虫病防治站，湖北省江陵县血吸虫病防治站 武汉 430071，武汉 430071，武汉 430071，武汉 430071，江陵 434100，江陵 434100 |
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| 摘 要： | 对30例巨脾型和19例已切脾的晚期血吸虫病(晚血)患者及 41例对照人群进行外周血 NK细胞活性、红细胞C_(3b)受体花环率、中性粒细胞吞噬功能和淋巴细胞转化试验测定以检测晚血患者的细胞免疫功能变化及脾切除对其影响。结果显示,晚血巨脾型患者上述免疫功能均明显低于对照人群,切脾患者 NK细胞活性、红细胞C_(3b)受体花环率明显高于巨脾组。晚血患者中性粒细胞吞噬指数及淋巴细胞转化功能已呈抑制,但切脾组与巨脾组之间无明显差异。表明脾切除不仅能降低门脉高压,同时也有可能改善患者的细胞免疫调节功能,增加患者抵抗力。
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| 关 键 词： | 晚期血吸虫病 巨脾 细胞免疫 脾切除 |
EFFECT OF SPLENECTOMY ON DISORDER OF CELLULAR IMMUNOREGULATION IN PATIENTS WITH ADVANCED SCHISTOSOMIASIS |
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| Ma Bei-Yang,Gui Xien,Yang Zi-Chen,Xiong Yiong,Wang Hou-Cheng,Wang Zhen-Bin Second Affiliated Hospital,Hubei Medical College,Wuchang Institute of Schistosomiasis of Jiangling County,Hubei. EFFECT OF SPLENECTOMY ON DISORDER OF CELLULAR IMMUNOREGULATION IN PATIENTS WITH ADVANCED SCHISTOSOMIASIS[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1993, 0(4) |
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| Authors: | Ma Bei-Yang Gui Xien Yang Zi-Chen Xiong Yiong Wang Hou-Cheng Wang Zhen-Bin Second Affiliated Hospital Hubei Medical College Wuchang Institute of Schistosomiasis of Jiangling County Hubei |
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| Affiliation: | Ma Bei-Yang,Gui Xien,Yang Zi-Chen,Xiong Yiong,Wang Hou-Cheng,Wang Zhen-Bin Second Affiliated Hospital,Hubei Medical College,Wuchang 430071 Institute of Schistosomiasis of Jiangling County,Hubei 434100 |
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| Abstract: | The peripheral blood natural killer(NK)cell activity,the percentage of E-C,bR rosettes, phagocytosis of neutrophil and lymphocyte blastogenesis were studied to assess the cellular immunoregulation in patients with advanced schistosomiasis.The results showed that the NK cell activity and the percentage of E-C,bR rosettes were significantly lower in patients with splenomegaly than in patients who had undergone splenectomy and in normal subjects.The phagocytic index of neutrophil and lymphocyte blastogenesis was reduced in patients with advanced schistosomiasis,but no significant difference was found between the patients with and without splenectomy.These results suggested that splenectomy not only reduce the portal hypertension but also improve the regulatory functions of cellular immunity which may enhance the patient's resistance against pathogens. |
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| Keywords: | Advanced schistosomiasis splenomegaly cellular immunity splenectomy |
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