高血压合并葡萄糖调节受损患者血浆妊娠相关蛋白A水平变化及相关因素研究

目的探讨高血压合并葡萄糖调节受损（IGR）患者血浆妊娠相关蛋白A（PAPP-A）水平变化及其与血压、WHR、血糖、血脂、血浆胰岛素、高敏C反应蛋白（hs-CRP）水平等的关系。方法酶联免疫吸附法测定IGR患者（IGR组）、高血压合并IGR患者（HT＋IGR组）和正常人（NC组）血浆PAPP-A水平,分析其与血压、BMI、WHR、血脂、HOMA-IR、hs-CRP等的关系。结果 HT＋IGR组血浆PAPP-A水平明显高于IGR组和NC组（P〈0.01）。血浆PAPP-A水平与年龄、体重、腰围、臀围、舒张压（DBP）、体内脂肪百分比（FAT%）、BMI、WHR、TG、FFA、FPG、2hPG、FIns2、hPIns、HOMA-IR、hs-CRP、HbAlc呈正相关。多元回归分析结果表明腰围、DBP、2hPIns、HbAlc是影响血浆PAPP-A水平的独立相关因素。结论血浆PAPP-A水平的改变与糖脂代谢和血压等有关,并可能参与了胰岛素抵抗及高血压合并糖尿病的发生发展。

Study of correlations among plasma pregnancy associated plasma protein-A relevant factors in hypertension patients with impaired glucose regulation

Objective: To investigate the changes of plasma pregnancy associated plasma protein-A(PAPP-A) level and the relationship among plasma PAPP-A level and blood pressure,waist hip ratio(WHR),blood lipids,blood glucose,plasma insulin,plasma highly sensitive C-reactive protein(hs-CRP) levels as well as other factors in hypertension patients with impaired glucose regulation(IGR).Methods: Plasma PAPP-A levels were assayed by ELISA in the IGR(IGR),hypertension patients with IGR(HT+IGR) and normal controls(NC).The re...