| 2型糖尿病患者并发糖尿病视网膜并发症多重危险因素分析 |
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| 引用本文： | 张新焕,宋晓,陈圆圆,邓仰欣. 2型糖尿病患者并发糖尿病视网膜并发症多重危险因素分析[J]. 泰山医学院学报, 2011, 32(9): 656-659 |
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| 作者姓名： | 张新焕 宋晓 陈圆圆 邓仰欣 |
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| 作者单位： | 泰山医学院临床学院,山东泰安,271000 |
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| 摘 要： | 研究背景和目的糖尿病视网膜病变（diabetic retinopathy，DR）是糖尿病（DM）患者最常见，最严重的微血管并发症之一，除遗传因素外，环境因素在DR的发生发展中起着非常重要的作用。本研究旨在探讨2型糖尿病患者易于发生视网膜并发症的多重危险因素。材料与方法随机选择无亲缘关系的T2DM患者274例和120例健康个体，均为汉族人。分为正常对照组、单纯糖尿病组、糖尿病视网膜病变组三个病例组，搜集相应的临床资料并检测有关临床与生化指标，对不同组间的临床与生化指标进行统计分析，并对糖尿病患者易发视网膜病变的危险因素进行logistic回归分析。结果糖尿病视网膜病变组糖化血红蛋白水平、血脂水平，血管内皮生长因子（VEGF）水平以及合并肾脏病变的比率显著高于单纯糖尿病组，而C肽水平显著低于单纯糖尿病组，多重回归显示血管内皮生长因子（VEGF）水平，LDL、TC、HbA1c水平，合并肾脏病变与糖尿病视网膜病变发生呈正相关。结论VEGF、LDL、TC、TG、HbA1c、合并肾脏病变可能是2型糖尿病易发视网膜病变的独立危险因素。
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| 关 键 词： | 2型糖尿病 糖尿病视网膜病变 血管内皮生长因子 |
The study of risk factors related to diabetic retinopathy in Type 2 Diabetes mellitus |
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| ZHANG Xin-huan,SONG Xiao,Chen Yuan-yuan,DENG Yang-xin. The study of risk factors related to diabetic retinopathy in Type 2 Diabetes mellitus[J]. Journal of Taishan Medical College, 2011, 32(9): 656-659 |
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| Authors: | ZHANG Xin-huan SONG Xiao Chen Yuan-yuan DENG Yang-xin |
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| Affiliation: | ZHANG Xin-huan SONG Xiao Chen Yuan-yuan DENG Yang-xin(Dept.of Endocrinology,The Affiliated Hospital of Taishan Medical University,Taian 271000,China) |
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| Abstract: | Objective: To investigate the probalble risk factors related to the devolepment of diabetic retinopathy.Methods: All subjects randomly recruited in this study were divided into DR group(diabetic retinopathy group),NDR group(type 2 diabetes without retinopathy group) and normal control group.Clinical characteristics were collected and biochemical indexes were measured of all the subjects.All calculations were performed using the SPSS 10.0 version for Windows.Result: The levels of HbA1c,TC,LDL-C,TG,VEGF were ... |
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| Keywords: | type 2 diabetes diabetic retinopathy vascular endothelial growth factor |
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