| 丹参对糖尿病大鼠肾组织VEGF表达的影响及其保护作用 |
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| 引用本文： | 黄晓磊,王晓东.丹参对糖尿病大鼠肾组织VEGF表达的影响及其保护作用[J].泰山医学院学报,2011,32(7):503-506. |
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| 作者姓名： | 黄晓磊 王晓东 |
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| 作者单位： | 泰山医学院附属泰山医院,山东泰安,271000 |
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| 摘 要： | 目的探讨丹参对糖尿病大鼠肾组织血管内皮生长因子（VEGF）表达的影响及其保护作用。方法采用腹腔注射链脲佐菌素制备糖尿病大鼠模型。随机分为正常对照组、糖尿病模型组和丹参治疗组。给药8周后,观察各组大鼠血糖（BG）、体质量（BW）、肾质量/体质量（KW/BW）、血尿素氮（BUN）、胆固醇（CHO）、内生肌酐清除率（Ccr）、尿白蛋白排泄率（UAER）,行肾组织HE染色,观察肾组织病理形态学改变,采用免疫组化方法分析肾组织VEGF蛋白的表达情况。结果糖尿病模型组各生化指标与正常对照组存在明显差异（P〈0.01）;丹参治疗组较模型组KW/BW降低（P〈0.05）,Ccr明显升高（P〈0.01）,BUN、CHO、UAER明显降低（P〈0.01）。糖尿病模型组较正常对照组肾组织VEGF蛋白表达明显升高（P〈0.01）;丹参治疗组较模型组肾组织VEGF蛋白表达降低（P〈0.05）。结论丹参对糖尿病大鼠肾功能具有保护作用,其机制可能是调节肾组织VEGF的表达,从而减轻肾脏病理损害,发挥其保护作用。
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| 关 键 词： | 丹参 糖尿病肾病 血管内皮生长因子 |
Influence of Salvia miltiorrhiza on expression of VEGF in kidney tissue in experimental diabetic nephropathy rats and its curative effects |
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| HUANG Xiao-lei,WANG Xiao-dong.Influence of Salvia miltiorrhiza on expression of VEGF in kidney tissue in experimental diabetic nephropathy rats and its curative effects[J].Journal of Taishan Medical College,2011,32(7):503-506. |
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| Authors: | HUANG Xiao-lei WANG Xiao-dong |
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| Institution: | HUANG Xiao-lei WANG Xiao-dong (Central Hospital of Taian City,Taian 271000,China) |
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| Abstract: | Objective: To investigate the influence of Salvia miltiorrhiza on expression of VEGF in the kidney of diabetic rats and its curative effects.Methods:Streptozotocin(STZ) was injected through abdominal cavity to make models of diabetic rats.Wistar rats were randomly divided into the normal control rat group,the model control group and Salvia miltiorrhiza curative group.After administration for 8 weeks,the rats were observed in their indexes of blood glucose(BG),body weight(BW),kidney weight/ body weight(KW/BW... |
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| Keywords: | Salvia miltiorrhiza diabetic nephropathy VEGF |
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