| 吗啡对糖奖赏剥夺所致大鼠挫折反应的抑制作用 |
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| 引用本文： | 刘青,梁建辉,Jun-Xu Li,Li Jing,Min Zhang,Wang-Jun Qin,Yan-Ting Wang.吗啡对糖奖赏剥夺所致大鼠挫折反应的抑制作用[J].中国神经再生研究,2011,6(28):2211-2216. |
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| 作者姓名： | 刘青 梁建辉 Jun-Xu Li Li Jing Min Zhang Wang-Jun Qin Yan-Ting Wang |
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| 作者单位： | 北京大学中国药物依赖性研究所,北京大学中国药物依赖性研究所,Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA 14214.,National Institute on Drug Dependence, Peking University, Beijing 100191, P.R. China.,National Institute on Drug Dependence, Peking University, Beijing 100191, P.R. China.,National Institute on Drug Dependence, Peking University, Beijing 100191, P.R. China.,National Institute on Drug Dependence, Peking University, Beijing 100191, P.R. China. |
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| 基金项目： | 国家自然科学基金, No. 30870894, 国家基础研究项目, No. 2009CB522000, “十二五”国家重要技术与研发项目, No. 2011BAK04B08. |
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| 摘 要： | In this study,a T-maze-based frustration model in rats was established using sucrose-reward de-privation.The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase.During the sucrose-deprivation frustration phase,both the preference for the sucrose-deprivation arm (62.5%) and time spent waiting in the sucrose-deprivation arm decreased.Acute injection of morphine increased the preference in a dose-dependent fashion,and prolonged the waiting duration in the sucrose-deprivation arm.These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation.To further elucidate the pharmacological mechanisms involved,the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine.The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment.These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.
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| 关 键 词： | frustration morphine sucrose reward deprivation T-maze naloxone |
Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats |
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| Liu Qing,Liang Jian-Hui,Jun-Xu Li,Li Jing,Min Zhang,Wang-Jun Qin and Yan-Ting Wang.Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats[J].Neural Regeneration Research,2011,6(28):2211-2216. |
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| Authors: | Liu Qing Liang Jian-Hui Jun-Xu Li Li Jing Min Zhang Wang-Jun Qin and Yan-Ting Wang |
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| Institution: | National Institute on Drug Dependence, Peking University,National Institute on Drug Dependence, Peking University,,Department of Physiology, Tianjin Medical University, Tianjin 30070, P.R. China.,,, |
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| Abstract: | In this study, a T-maze-based frustration model in rats was established using sucrose-reward de-privation. The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm (62.5%) and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. To further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor. |
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| Keywords: | frustration morphine sucrose reward deprivation T-maze naloxone |
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