| p75NTR对小鼠面神经损伤后脑内神经元再生的影响 |
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| 引用本文： | 张风河,魏奉才,杨丕山,孙善珍. p75NTR对小鼠面神经损伤后脑内神经元再生的影响[J]. 口腔颌面外科杂志, 2007, 17(2): 139-142 |
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| 作者姓名： | 张风河 魏奉才 杨丕山 孙善珍 |
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| 作者单位： | 1. 山东大学口腔医学院口腔颌面外科,山东,济南,250012
2. 山东大学齐鲁医院口腔科,山东,济南,250012 |
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| 基金项目： | 感谢澳大利亚弗林德丝大学Xin-fu Zhou教授在本研究中的的帮助 |
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| 摘 要： | 目的:探讨p75NTR在面神经损伤后面神经核运动神经元再生中的作用。方法:对p75基因敲除小鼠和野生型小鼠的面神经总干进行损伤,损伤后第4天,在面神经总干损伤的远中侧神经分叉处切断,将切断的面神经断端置入含有FastBlue的聚乙烯单端小管中进行后示踪标记,术后第7天冷冻切片后荧光显微镜下对面神经核运动神经元进行计数,然后进行统计分析。结果:两组之间再生的神经元数量有显著性差异(P<0.05)。结论:p75NTR可以促进面神经运动神经元的再生。
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| 关 键 词： | P75神经营养蛋白受体 FastBlue 再生 小鼠,基因敲除 |
| 文章编号： | 1005-4979（2007）02-0139-04 |
| 收稿时间： | 2006-01-26 |
| 修稿时间： | 2006-01-26 |
Role of P75NTR in the Motoneurons Survival of Facial Nerve Neuclei after the Facial Nerve Injury in Mouse |
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| ZHANG Feng-he,WEI feng-cai,YANG Pi-shan,SUN Shan-zhen. Role of P75NTR in the Motoneurons Survival of Facial Nerve Neuclei after the Facial Nerve Injury in Mouse[J]. Chinese Journal of Oral and Maxillofacial Surgery, 2007, 17(2): 139-142 |
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| Authors: | ZHANG Feng-he WEI feng-cai YANG Pi-shan SUN Shan-zhen |
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| Affiliation: | 1.Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan 250012; 2.Department of Stomatology, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China |
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| Abstract: | Objective: To investigate the role of p75NTR in the regeneration of facial nerve nuclei during nerve crush injury. Methods: At the 4th day after injury of facial nerve, nerve trunk was cut in the bifurcated region and the stump was inserted into a small polymer tube containing Fast blue. Retrograde tracing and labelling motoneuron counting were used to examine the survival of motoneurons in the facial nerve nuclei in p75 knock-out mice and wild type mice respectively. Results: Retrograde tracing showed that the number of survival motoneurons from the p75 knock-out mice was much fewer than those from the wild type mice(P<0.05). Conclusion: p75NTR can promote the survival rate of motoneurons in the facial nerve nuclei after nerve injuries. |
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| Keywords: | p75NTR Fast Blue regeneration mouse knock-out |
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