| 阿立哌唑治疗阿尔茨海默病行为和精神症状的临床对照研究 |
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| 引用本文： | 李韬,刘小琴,李晓玲,孙艳,廖秋莲.阿立哌唑治疗阿尔茨海默病行为和精神症状的临床对照研究[J].中国医药指南,2011,9(19):26-27. |
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| 作者姓名： | 李韬 刘小琴 李晓玲 孙艳 廖秋莲 |
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| 作者单位： | 湖南省娄底市康复医院,湖南,娄底,417000 |
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| 摘 要： | 目的探讨阿立哌唑治疗阿尔茨海默病(AD)行为和精神症状(BPSD)的疗效和安全性。方法 72例AD伴BPSD患者随机分为阿立哌唑组37例,利培酮组35例,疗程8周,采用Cohen-Mansfield(CMAI)激越问卷和痴呆病理行为量表(BEHAVE-AD)评定疗效,采用副反应量表(TESS)评定副反应。结果阿立哌唑组总有效率86.5%,利培酮组总有效率85.7%,组间比较差异无统计学意义(P>0.05),组内比较差异有显著统计学意义(P<0.01)。两组不良反应比较,阿立哌唑组EPS发生率明显低于利培酮组,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮治疗AD伴发BPSD均有较好疗效,两者总体疗效、起效时间相当,而阿立哌唑的安全性及不良反应优于利培酮。
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| 关 键 词： | 阿立哌唑 阿尔茨海默病 痴呆行为和精神症状 |
Clinical Control Study of Aripiprazole Treatment of Behavioral and Psychological Symptoms of Alzheimer's Disease |
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| LI Ren,LIUXiao-Qin,LI Xiao-ling,SUN Yan,LIAO Qiu-lian.Clinical Control Study of Aripiprazole Treatment of Behavioral and Psychological Symptoms of Alzheimer's Disease[J].Guide of China Medicine,2011,9(19):26-27. |
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| Authors: | LI Ren LIUXiao-Qin LI Xiao-ling SUN Yan LIAO Qiu-lian |
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| Institution: | LI Ren,LIU Xiao-Qin,LI Xiao-ling,SUN Yan,LIAO Qiu-lian(Loudi Kangfu Hospital,Loudi 417000,China) |
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| Abstract: | Objective To evaluate the aripiprazole treatment of Alzheimer disease(AD) behavioral and psychological symptoms(BPSD) of the efficacy and safety.Methods 72 cases of AD with BPSD were randomly divided into aripiprazole group 37 cases and risperidone 35 cases treated for 8 weeks,using Cohen-Mansfield(CMAI) agitation inventory and pathological behavior dementia scale(BEHAVE-AD) evaluate the efficacy,the use of side effects scale(TESS) assessment of side effects.Results Aripiprazole total effective rate was 86.... |
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| Keywords: | Aripiprazole Alzheimer's disease Behavioral and psychological symptoms of dementia |
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