结核分枝杆菌耐药性分析

目的:回顾性分析结核分枝杆菌耐药状况。方法:分析分离培养出并使用噻吩-2羧基肼(TCH)和对硝基苯甲酸(PNB)进行分型确认的127株结核分枝杆菌药物敏感试验结果,包括异烟肼(H)、利福平(R)、链霉素(S)、乙胺丁醇(E)、吡嗪酰胺(Z)、力克肺疾(D)、氧氟沙星(O)、丙硫乙烟胺(TH)、卷曲霉素(C)、对氨基水杨酸钠(P)、丁胺卡那(AK)。11种药物采用绝对浓度法进行药物敏感性检测。结果:127株结核分枝杆菌中,R耐药率最高,高浓度药物耐药达74%、C耐药率最低,高浓度药物耐药率为3.9%;HR联合耐药率为67.7%,HRS联合耐药率为52%,CThZ联合耐药率为9.4%,同时对7种药物耐药的耐药率为39.4%,同时对11种药物的耐药率为11%。结论:结核分枝杆菌耐药情况已很严重,需要更严格的执行结核病预防和治疗。

Investigation on the Drug Resistance Status of Mycobacterium Tuberculosis Strains

Objective:To analyze retrospectively the status of drug resistance of mycobaeterium tuberculosis.Methods:127 strains mycobacterium tuberculosis were identified by TCH and PNB.We analyzed the results of drug susceptibility testing by absolute concentration among 11 drugs,including H,R,S,E,2,D,O,TH,C,P,AK.Results.Of 127 strains mycobaeterium tuberculosis,high concentrations of H resistance rate is 74%,high concentrations of C resistance rate is 3.9%,67.7%isolates were resistant to HR drugs,52%were resistant to HRS drugs,9.4%were resistant to CThZ drugs,39.4%isolates were resistant to all seven drugs,11%were resistant to all eleven drugs.Conclusion: The situation of drug resistance is very serious.More strict execution should be taken to prevent and treat tuberculosis.