| 怡心饮对糖尿病心脏病大鼠心肌CTGF-mRNA和MCP-1mRNA表达的影响 |
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| 引用本文： | 王海颖,陈城,陆敏,鲍君璐. 怡心饮对糖尿病心脏病大鼠心肌CTGF-mRNA和MCP-1mRNA表达的影响[J]. 中西医结合心脑血管病杂志, 2012, 10(9): 1086-1088 |
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| 作者姓名： | 王海颖 陈城 陆敏 鲍君璐 |
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| 作者单位： | 上海中医药大学 |
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| 基金项目： | 上海市科委自然科学基金项目(No.10ZR1428600);上海市教委方剂学重点学科建设项目子项目(No.z09011-03) |
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| 摘 要： | 目的观察怡心饮对糖尿病心脏病大鼠心脏单核趋化因子1(MCP-1)和结缔组织生长因子(CTGT)mRNA表达的影响。方法运用高糖高脂饲料加链脲佐菌素腹腔注射建立大鼠2型糖尿病心肌病模型,分为怡心饮高剂量组、怡心饮低剂量组、生脉饮对照组、正常组、模型组。灌胃治疗8周后,观察糖尿病心肌病大鼠的心脏单核趋化因子1和结缔组织生长因子mRNA的表达,以及血清结缔组织生长因子的变化,分析其减轻大鼠心肌病变的机制。结果怡心饮能明显降低大鼠心肌单核趋化因子1和结缔组织生长因子mRNA表达,降低大鼠血清结缔组织生长因子含量。结论怡心饮对糖尿病大鼠心肌病变有一定的改善作用,其作用机制可能与降低单核趋化因子1和结缔组织生长因子mRNA的表达有关。
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| 关 键 词： | 怡心饮 结缔组织生长因子 单核趋化因子1 糖尿病 大鼠 |
Effect of Yixin Yin on Expression of CTGF mRNA and MCP-1 mRNA of Myocardium in Diabetic Cardiomyopathy Rats |
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| Affiliation: | Wang Haiying,Chen Cheng,Lu Min,et al // Shanghai University of Tradional Chinese Medicine(Shanghai 201203) |
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| Abstract: | Objective To investigate the influence of Yixin Yin on the expression of connective tissue growth factor(CTGF) and monocyte chemotactic protein-1(MCP-1) of diabetes mellitus(DM) rats and its protective mechanism.Methods Rats with type 2 DM(T2DM) cardiomyopathy model was established by high sugar,fat feed and chain bacteria intraperitoneal injection of urea.Rats were divided into the Yixin Yin high-dose group,low-dose group,Shengmai Yin control group,normal group,and model group.After treatment for 8 weeks,myocardial MCP-1 mRNA and CTGF mRNA expression were observed.Results The levels of myocardial MCP-1 mRNA,CTGF mRNA expression and serum CTGF were significantly decreased in Yixin Yin groups.Conclusion Yixin Yin could reduce the expression of myocardial CTGF-mRNA and MCP-1 mRNA in DM rats with cardiomyopathy. |
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| Keywords: | Yixin Yin connective tissue growth factor monocyte chemotactic protein-1 diabetes mellitus |
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